Results 111 to 120 of about 1,765,259 (347)

Partisan politics and fiscal policy [PDF]

open access: yes
Does the partisan character of governing parties play a role in the formation of fiscal policy? The conventional view is that the left tends toward excessive deficits while the right practices a more prudent and restrictive fiscal policy.
Cusack, Thomas R.
core  

Advance Directives Under State Law and Judicial Decisions (Medical Decision-Making and the ‛Right to Die’ After Cruzan) [PDF]

open access: yes, 1991
In the decision of the United States Supreme Court in Cruzan v. Director, Missouri Department of Health on June 25, 1990, a majority of the Court announced that it will leave to the states the question of what legal requirements may be imposed on ...
Areen, Judith C.
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

After Bangladesh, Labor Unions Can Save Lives [PDF]

open access: yes, 2013
[Excerpt] The factory collapse in Bangladesh that killed more than 1,100 workers should be a pivot point for the global apparel industry, moving consumers to demand more accountability from brand-name companies that subcontract production to supply-chain
Compa, Lance A
core   +1 more source

Transformations des conditions du mourir et nouvelles formes de socialisation à la mort

open access: yesDroit et Cultures, 2018
This article shows that the process of end-of-life individualization cannot be dissociated from the recent emergence of new forms of socialization to death and dying.
Michel Castra
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

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