Results 181 to 190 of about 1,791,801 (336)

A case for the provision of assisted dying in prisons founded on the right to self-determination: Creating equivalence between prisoners and non-prisoners?

, 2022
Helen Fenwick, Philippa Tomczak, Alasdair Cochrane   +2 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

"To die peacefully without pain...I want the right to have that choice!" : discursive constructions of euthanasia in the Aotearoa New Zealand media : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Psychology (with an endorsement in Health Psychology) at Massey University, (Distance), Aotearoa, New Zealand

, 2019
Amanda Booth
openalex   +1 more source

The Right to Die in Dignity and Comfort [PDF]

, 2007
Jung-Gi Im
openalex   +1 more source

Bene Mori: The Right of the Patient to Die with Dignity [PDF]

, 1975
Cavanagh, John R.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Targeting the metabolic flexibility of cancer cells: Straighten up and die right

, 2011
Isaac Marin‐Valencia, Ralph J. DeBerardinis   +1 more
openalex   +2 more sources

Federalism and the Right to Travel: Medical Aid in Dying and Abortion

, 2023
Leslie P. Francis, John G. Francis
openalex   +1 more source

Right to Life, Right to Die

Beytulhikme An International Journal of Philosophy, 2020
openaire   +1 more source