Results 61 to 70 of about 4,344,934 (307)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
, 2015 Governmental leaders, scholars, and activists have advocated for human rights to food, water, education, health care, and energy. Such rights, also called positive rights, place an affirmative duty upon the state to provide a minimum quantity and quality
Larson, Rhett B.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
INVOLVEMENT AND SOCIAL COMMITMENT - EXPERIENCE OF DIFFERENTIATED EDUCATION [PDF]
Revista Gestão & Saúde, 2014 This article is the result of a partnership Project New Extension Colors ( NUCEPEC UFC ) with a Center of Children 's Education, a district of Fortaleza , which consisted ten workshops , with an average of an hour and a half long with adolescents aged ...
Fabiana Pinto de Almeida Bizarria +3 more
doaj
School dropouts or pushouts? Overcoming barriers for the right to education [PDF]
, 2010 Persistently high dropout rates are one of the biggest challenges to fulfilling the right to education in India. This paper attempts to assess the magnitude of the problem of dropout.
Reddy, Anugula N., Sinha, Shantha
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Same-sex marriage and the Irish Constitution [PDF]
, 2009 This paper examines the recent Irish High Court case of Zappone and Gilligan v. Revenue Commissioners and others, a challenge to the constitutionality of the state’s interpretation of the Irish Tax Code vis-à-vis the foreign marriage of a same-sex couple
O'Sullivan, Aisling
core +2 more sources
Effectiveness of an Eye-Cervical Re-Education Program in Chronic Neck Pain: A Randomized Clinical Trial [PDF]
, 2020 Objectives. Proprioceptive training is popularly applied as a therapeutic exercise method in physiotherapy. Its effects on pain and range of motion are only poorly evaluated.
Chamorro-Moriana, Gema +5 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Costs of a “Free” Education: The Impact of Schaffer v. Weast and Arlington v. Murphy on Litigation under the IDEA [PDF]
, 2007 The Individuals with Disabilities Education Act guarantees to children with disabilities the right to receive a free appropriate public education. This Note argues that the Supreme Court decisions Schaffer v. Weast and Arlington v.
Thomason, Kelly D.
core +1 more source