Results 51 to 60 of about 2,094,932 (355)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Costs of the COVID-19 vaccination programme: estimates from the West Rand district of South Africa, 2021/2022

BMC Health Services Research
Background The COVID-19 vaccination programme in South Africa was rolled out in February 2021 via five delivery channels- hospitals, primary healthcare (PHC), fixed, temporary, and mobile outreach channels.
Ijeoma Edoka, Lineo Marie Matsela, Khumo Modiba, Yolandie Luther, Sharlene Govender, Thapelo Maotoe, Heena Brahmbhatt, Pedro T. Pisa, Gesine Meyer-Rath, Jacqui Miot   +9 more
doaj   +1 more source

Varying intervals of antiretroviral medication dispensing to improve outcomes for HIV patients (The INTERVAL Study): study protocol for a randomized controlled trial

Trials, 2017
Background Requirements for frequent dispensing of antiretroviral therapy (ART) place demands on health systems and can lead to suboptimal adherence and disengagement in care for patients due to the time and cost of frequent clinic visits.
Risa Hoffman, Ashley Bardon, Sydney Rosen, Matthew Fox, Thoko Kalua, Thembi Xulu, Angela Taylor, Ian Sanne   +7 more
doaj   +1 more source

Health and legal literacy for migrants: twinned strands woven in the cloth of social justice and the human right to health care

BMC International Health and Human Rights, 2017
BackgroundBased on an analysis of published literature, this paper provides an over-view of the challenges associated with delivering on the right to access quality health care for international migrants to industrialized countries, and asks which group ...
B. Vissandjée, Wendy E Short, Karine Bates   +2 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Similar costs and outcomes for differentiated service delivery models for HIV treatment in Uganda

BMC Health Services Research, 2022
This cost-outcome study estimated, from the perspective of the service provider, the total annual cost per client on antiretroviral therapy (ART) and total annual cost per client virally suppressed (defined as  18 years old) enrolled in a DSDM. The study
Teresa Guthrie, Charlotte Muheki, Sydney Rosen, Shiba Kanoowe, Stephen Lagony, Ross Greener, Jacqueline Miot, Hudson Balidawa, Josen Kiggundu, Jacqueline Calnan, Seyoum Dejene, Thembi Xulu, Ntombi Sigwebela, Lawrence C Long   +13 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

A Right to Health Care

Journal of Law, Medicine & Ethics, 2012
Do we have a legal and moral right to health care against others? There are international conventions and institutions that say emphatically yes, and they summarize this in the expression of “the right to health,” which is an established part of the international human rights canon. The International Covenant on Social and Economic Rights outlines this
openaire   +3 more sources

[Legal remedies: therapeutic markets and the judicialization of the right to health].

História, Ciências, Saúde: Manguinhos, 2016
This study draw on the struggle of parents of children with mucopolysacchar idosis to access expensive drugs in the name of universal right to health. The work explores how, in Brazil, right-to-health litigation became an alternative pathway to access ...
João Biehl, Adriana Petryna
semanticscholar   +1 more source