Results 41 to 50 of about 130,293 (294)

Gendering the right to housing in the city: Homeless female lone parents in post-Olympics, austerity East London

open access: yesCities, 2017
This paper assesses how gender, housing, austerity and the right to the city inter-relate with reference to female lone parents from East London, the site of the 2012 Olympic Games.
P. Watt
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Multi‐Actor Housing to Address Vulnerabilities at a Personal and Local Level

open access: yesSocial Inclusion
In response to an everlasting housing crisis, cities worldwide have witnessed a surge in alternative housing initiatives (AHIs) driven by third‐sector organisations. In Brussels, a network of third‐sector organisations has been developing strategies with
Aikaterini Anastasiou   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

The right to housing as a component of the right to an adequate standard of living: issues of implementation amidst Ukraine’s housing stock destruction and solutions

open access: yesBulletin of Kharkiv National University of Internal Affairs, 2023
This article presents a comprehensive analysis of the right to housing, framing it as an essential component of the broader right to an adequate standard of living.
V. V. Maltsev
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Le balene sconfiggono i confini. Appunti per una narrazione fra storie familiari e spazi urbani

open access: yesCambio, 2016
The article is an ethnographic text and it concerns those people that the society defines “marginal”, “excluded” or “poor”; notions used in a critical approach. The narrative discourse used is the expression of the narrative mode of thinking that «deals -
Sabrina Tosi Cambini
doaj   +1 more source

Improvement of the mechanism for provision of housing subsidies in modern Ukraine

open access: yesЕкономіка, управління та адміністрування, 2021
The article substantiates the theoretical provisions and develops practical recommendations for improving the mechanism of providing housing subsidies in modern Ukraine.
D.V.
doaj   +1 more source

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