Results 41 to 50 of about 136,266 (300)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Multi‐Actor Housing to Address Vulnerabilities at a Personal and Local Level

open access: yesSocial Inclusion
In response to an everlasting housing crisis, cities worldwide have witnessed a surge in alternative housing initiatives (AHIs) driven by third‐sector organisations. In Brussels, a network of third‐sector organisations has been developing strategies with
Aikaterini Anastasiou   +3 more
doaj   +1 more source

The Right to Housing: During and After the Covid-19 Pandemic

open access: yesIus Humani, 2021
The importance of ensuring the right to housing during the pandemic Covid-19 and avoiding its negative impact on all spheres of human life is multifaceted.
Bohdan Fasii   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Housing Rights in Ireland

open access: yes, 2003
Ireland has been the world leader in house price inflation since 1996, and has reached the highest level of home ownership among the OECD countries.1 Irish government housing policy has given the market a primary role in the production and allocation of new housing.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Homeless women’s path towards social inclusion: an analysis of social housing models in Italy [PDF]

open access: yes, 2022
openHomelessness represents a growing phenomenon and a serious violation of the right to adequate housing. The recent urban modernisation, the organisation of sporting events and the frequent migration flows have worsened the housing situation, which ...
LIO, MIRANDA
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Le balene sconfiggono i confini. Appunti per una narrazione fra storie familiari e spazi urbani

open access: yesCambio, 2016
The article is an ethnographic text and it concerns those people that the society defines “marginal”, “excluded” or “poor”; notions used in a critical approach. The narrative discourse used is the expression of the narrative mode of thinking that «deals -
Sabrina Tosi Cambini
doaj   +1 more source

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