Results 61 to 70 of about 130,293 (294)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Houses need to breathe--right? [PDF]
, 2004 Houses need to breathe, but we can no longer leave the important functions associated with ventilation to be met accidentally. A designed ventilation system must be considered as much a part of a home as its heating system. Windows are a key part of that system because they allow a quick increase in ventilation for unusual events, but neither they nor ...
openaire +4 more sources
Housing First programs from a right to housing perspective
, 2021 The notion that Housing First (HF) is a human-rights based approach to housing some of society’s most vulnerable citizens is often alluded to in the literature, but seldom interrogated. In this paper, we examine whether HF in Alberta, Canada is practiced in a way that realizes the right to housing for chronically homeless people.
Stadler, Sophie L., Collins, Damian
openaire +2 more sources
The Power of Human Rights/The Human Rights of Power, 2015 Critics of human rights are hesitant to reject them outright for fear of undermining the work they may do in resisting oppression. This pragmatic justification is central to celebrations of human rights as well, but is it more than a failure to move ...
J. Hoover
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
As políticas habitacionais e as ocupações urbanas: dissenso na cidade
Cadernos MetrópoleResumo O artigo trata do enfrentamento cotidiano no acesso ao direito à moradia e à cidade. Como pano de fundo do debate teórico, têm-se as ocupações urbanas em contraponto aos empreendimentos do Programa Minha Casa Minha Vida em Belo Horizonte, diante ...
Denise Morado Nascimento
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Urban Studies and Public AdministrationAbandoned buildings, degraded neighbourhoods, places designed without taking into consideration those who will inhabit them: the survival of the city today depends on the ability to reinterpret and reinvent the use of space by bringing together different interests and opportunities.
openaire +2 more sources