Results 121 to 130 of about 94,880,974 (260)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Right To Information Act and NREGA: Reflections on Rajasthan [PDF]

open access: yes
This article explores the role of Right to Information Act in effective Implementation of NREGA through checking corruption. For substantiating the core argument, the paper examines the success story of NREGA in Rajasthan.Section one of the article ...
Menon, Sudha Venu
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Gender and the right to mobility in South Asia [PDF]

open access: yes, 2016
"South Asia including Bangladesh, India, Nepal, Pakistan and Sri Lanka encompasses source, transit and destination areas for women who migrate for employment.
Bhattacharjee, Shikha Silliman   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Students’ Responses to a Scavenger Hunt for First Year Engineering Orientation

open access: yes, 2012
Orientation is an essential part of the transition into engineering studies at University. A successful orientation introduces students to their department and to university studies, providing important information and assisting the students in making ...
Lloyd, Natalie, Lindsay, Euan, Gray, S.
core  

The right to speedy trial [PDF]

open access: yes, 1992
A more liberal notion of prejudice than that so far adopted by the Hong Kong courts should be accepted. Prejudice short of actual impairment of the right to defend oneself should suffice for the purpose of a finding of a violation of the right to speedy ...
Chan, Man-mun, Johannes
core  

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