Results 151 to 160 of about 2,623,014 (293)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Terminal right coronary artery fistula to right ventricle

Brazilian Journal of Cardiovascular Surgery, 2013
Paulo Roberto B. Evora, Solange Bassetto, Alfredo J. Rodrigues   +2 more
doaj   +1 more source

Migrating Needle in Right Ventricle Wall With Purulent Tamponade. [PDF]

Am J Case Rep
Żuk A, Sałagaj M, Pszonak S, Makowicz G, Gajewski A, Zieliński D, Bilewska A, Budaj A, Wróbel K.   +8 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Post-myocardial infarction left ventricular aneurysm rupturing into the right ventricle. [PDF]

J Cardiothorac Surg
Zhang X, Aximu Y, Zhang P.
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT. [PDF]

J Nucl Med
Shanbhag A, Miller RJH, Kavanagh P, Ramirez G, Lemley M, Kwiecinski J, Kamagate A, Slipczuk L, Travin MI, Alexanderson E, Carvajal-Juarez I, Packard RRS, Al-Mallah M, Einstein AJ, Acampa W, Knight S, Le VT, Mason S, Wopperer S, Chareonthaitawee P, Rosamond TL, Berman DS, Dey D, Di Carli MF, Slomka PJ.   +24 more
europepmc   +1 more source

Rescuing the Right Ventricle

Rescuing the Right Ventricle. Dr. Aakriti Jain, IMRP R2, Rochester General Hospital; Dr. Elizabeth Lee, Cardiology Department, Rochester General Hospital.
Jain, Aakriti, Lee, Elizabeth
core  

Method for determining right ventricle stroke volume

, 2015
The present invention relates to a method for determining right ventricle stroke volume comprising the steps of: providing a plurality of three-dimensional images of right cardiac ventricle of a patient over a cardiac cycle; identically slicing each of ...
Rahmat, Rahmita Wirza O.K., Dimon, Mohd Zamrin, Kadiman, Suhaini, Abdullah, Lili Nurliyana, Saripan, M. Iqbal, Abboud, Anas A.   +5 more
core  

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source