Results 171 to 180 of about 2,720,449 (296)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Pulmonary Hypertension in Adults With a Systemic Right Ventricle (Biventricular Circulation). [PDF]

JACC Adv
Wilson WM, Aldweib N, Celermajer DS, Opotowsky AR, Dehghani P, Roos-Hesselink J, Dellborg M, Baker D, Aboulhosn J, Antonova P, Fernandes S, Ginde S, Han F, O'Donnell C, Rodriguez-Monserrate CP, Fusco F, John AS, Wong J, Yeung E, Sarubbi B, Pylypchuk S, Shah S, Kay J, Cramer J, Cotts T, Gupta T, Burchill LJ, Khairy P, Muhll IV, van Dissel A, Grewal J, Magalski A, Gallego P, Rodriguez F, Kuo M, Kauling RM, DeZorzi C, Krieger EV, Kutty S, Nicolarsen J, Broberg CS, Cheung M.   +41 more
europepmc   +1 more source

HAMARTOMA OF THE RIGHT VENTRICLE

The Journal of Thoracic and Cardiovascular Surgery, 1964
openaire   +2 more sources

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

The right ventricle as the Achilles' heel: tricuspid regurgitation and right heart failure in the era of mechanical circulatory support. [PDF]

Front Cardiovasc Med
Wu W, Wang S, Xu G, Liu F, Liu Z, Wu X, Gao X, Ge Z.   +7 more
europepmc   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Cardiac Myxoma Originating From the Septal Papillary Muscle of the Right Ventricle in a Second-Trimester Patient. [PDF]

Echocardiography
Zhou JJ, Dong QW, Song YT, Li RJ, Zhang HK, Gu XY, He YH.   +6 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Systemic Right Ventricle and Myocardial Bridging: Hemodynamics and Surgical Solutions in Adult Congenital Heart Disease. [PDF]

JACC Case Rep
de Almeida Neto ACE, Pereira Cavalcanti LR.   +1 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source