Results 121 to 130 of about 4,339,803 (292)

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Right Ventricular Myocardial Biomarkers in Human Heart Failure

, 2017
Background: Right ventricular (RV) dysfunction contributes to mortality in chronic heart failure (HF). However, the molecular mechanisms of RV failure remain poorly understood, and RV myocardial bio-markers have yet to be developed. Methods and Results:
楊鎧鍵, di Salvo, Thomas G.;Yang, Kai-Chien;Brittain, Evan;Absi, Tarek;Maltais, Simon;Hemnes, Anna   +1 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

A Rare Case of Ebstein’s Anomaly with Biventricular Noncompaction

Journal of Indian College of Cardiology
Ebstein’s anomaly is a rare cyanotic congenital heart disease, which can present with right heart failure when associated with septal defects and/or right ventricular outflow tract obstruction.
Immaneni Sathyamurthy, Anuradha Sridhar, Sasikala Subramanian, Zeeshan Sakina A. Lakhani   +3 more
doaj   +1 more source

Clinical and Echocardiographic Findings of Left Ventricular Diastolic Dysfunction Among Hypertensive Patients at Muhimbili National Hospital, Dar es Salaam [PDF]

, 2012
Hypertension is the commonest of the cardiovascular risk factors, whose prevalence in Tanzania is high between 20-30%, among rural and urban residents respectively.
Sanga, T.S, Sanga, Tulizo Shemu
core  

Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia.

, 2016
Differentiation between early-phase arrhythmogenic right ventricular cardiomyopathy (ARVC) and right ventricular outflow tract (RVOT)-ventricular tachycardia (VT) can be challenging, and correct diagnosis is important. We compared electrocardiogram (ECG)
Haugaa, Kristina, Einar Hopp, Trine F. Haland, Kristina H. Haugaa, Hopp, Einar, Rasmus Borgquist, Leren, Ida S, Ida S. Leren, Jan Otto Beitnes, Edvardsen, Thor, Saberniak, Jørg, Haland, Trine F, Jørg Saberniak, Haugaa, Kristina H, Beitnes, Jan Otto, Thor Edvardsen, Borgquist, Rasmus, Håland, Trine Synnøve Fink, Leren, Ida Skrinde   +18 more
core   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Acute right ventricular failure complicating catheter ablation for right ventricular tachycardia

HeartRhythm Case Reports, 2017
Nishaki Mehta, MD, Benjamin E. Peterson, MD, Roy M. John, MD, PhD   +2 more
doaj   +1 more source