Results 121 to 130 of about 9,237,904 (297)

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Right ventricular and tricuspid valve function in patients with two ventricular pacemaker leads

, 2004
Existing data on the effect of retained pacemaker leads on right ventricular (RV) and tricuspid valve function is ...
Arat-Ozkan, A, Uner, S, Yazicioglu, N, Celiker, C, Kucukoglu, MS, KÜÇÜKOĞLU, Mehmet Serdar, ÇELİKER, Cengiz, Alev Arat-Özkan, Cengiz Çeliker, Sinan Üner, Nuran Yazicioglu, M. Serdar Küçükoglu   +11 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

The Effects Of Right Ventricular Apical Pacing On Left Ventricular Function: Stimulation Of The Right Ventricular Apex: Should It Still Be The Gold Standard?

Indian Pacing and Electrophysiology Journal, 2003
Current pacing practice is undergoing continuous and substantial changes. Initially pacing had an exclusively palliative role, since it was reserved for patients developing complete heart block or severe symptomatic bradycardia.
T Szili-Torok, Thornton A
doaj  

Right and left ventricular function in hospitalized children with respiratory syncytial virus infection

, 2017
Thorsten Horter,1 Britt Nakstad,1,2 Omid Ashtari,1 Anne Lee Solevåg1 1Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, 2Institute of Clinical Medicine, Campus Akershus University Hospital, University ...
Ashtari O, Horter T, Nakstad B, Solevåg AL   +3 more
core  

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

The Association of the Pulmonary Artery Pulsatility Index and Right Ventricular Function after Cardiac Surgery

Critical Care Research and Practice
Background. The pulmonary artery pulsatility index (PAPi) has been shown to correlate with right ventricular (RV) failure in patients with cardiac disease.
Johnny Wei, Abigail Kee, Rachel Dukes, Jack Franke, Vincent Leonardo, Brigid C. Flynn   +5 more
doaj   +1 more source

Effects of pirbuterol and sodium nitroprusside on pulmonary haemodynamics in hypoxic cor pulmonale [PDF]

, 1983
The acute haemodynamic effects of oral pirbuterol (a beta-agonist) were contrasted with those of sodium nitroprusside, a vasodilator, in six patients with hypoxic chronic bronchitis and emphysema.
Wathen, C G, Macnee, William, Flenley, DC, Hannan, W J, Muir, A.L   +4 more
core  

Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members

, 2014
AimsExercise increases risk of ventricular arrhythmia in subjects with arrhythmogenic right ventricular cardiomyopathy (ARVC). We aimed to investigate the impact of exercise on myocardial function in ARVC subjects.
Haugaa, Kristina, Smith, Hans-Jorgen, Smith, Hans-Jørgen, Platonov, Pyotr,, Ribe, Margareth, Holst, Anders G., Hasselberg, Nina E., Edvardsen, Thor, Saberniak, Jørg, Platonov, Pyotr G, Sarvari, Sebastian Imre, Borgquist, Rasmus,, Holst, Anders G, Hasselberg, Nina Eide, Platonov, Pyotr, Borgquist, Rasmus, Lund University., Sarvari, Sebastian I., Haugaa, Kristina H., Saberniak, Jorg   +19 more
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source