Results 91 to 100 of about 2,531,746 (315)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Taking Back Control: Human Rights and Human Trafficking in the United Kingdom
SocietiesModern slavery and human trafficking are well recognized as significant problems in need of legislation, policies, and actions from a wide range of stakeholders in the United Kingdom.
Todd Landman +2 more
doaj +1 more source
Levosimendan: Right for the right ventricle?* [PDF]
Critical Care Medicine, 2007 Lambermont, Bernard +3 more
openaire +2 more sources
, 2015 Outlines the work the National Children\u27s Commissioner has undertaken throughout 2014-15 to promote discussion and awareness of matters relating to the human rights of children and young people in Australia.
Australian Human Rights Commission
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Genome MedicinePrecision oncology has facilitated a transition from a one-size-fits-all to a precise individualized approach. This Comment discusses the broader challenges in the implementation of personalized treatments to further improve patients' outcomes, towards comprehensive strategies that address tumor complexity and patients' molecular portfolios, as well as
Elena Fountzilas +2 more
openaire +3 more sources
Bureau of Labor and Industries' civil rights complaint process
, 2014 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on June 24, 2014)Converted ...
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War and peace: the ANZAC spirit and human rights [PDF]
, 2015 A series of papers given by the various speakers at the Australian Human Rights Commission’s War and Peace: The Anzac spirit and human rights 2014 seminar. Summary Every year around Anzac Day, Australians and New Zealanders remember those who fought in
Australian Human Rights Commission
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source