Results 121 to 130 of about 2,531,746 (315)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Economic, Social and Cultural Rights in Scotland

open access: yes, 2015
This briefing paper examines the status of economic, social and cultural (ESC) rights in Scotland. The purpose of the paper is to provide a clear explanation of what we mean by 'ESC' rights, how they are currently protected in Scotland and how they might
Boyle, Katie
core  

Pathways to protection: a human rights-based response to the flight of asylum seekers by sea [PDF]

open access: yes, 2016
The Commission has endeavoured to identify options for responding to flight by sea which are consistent with Australia’s international human rights obligations.
Australian Human Rights Commission
core  

Internal fight : Palestinian abuses in Gaza and the West Bank / Human Rights Watch

open access: yes, 2008
"This report documents serious human rights abuses over the past year by the competing Palestinian authorities in Gaza and the West Bank, run by Hamas and Fatah, respectively.
unknown
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Ancient, Medieval, and Early Modern Concepts of the Ius commune

open access: yesClio@Themis
“Ius commune” is the term that scholars use to describe the legal system that reigned on the European continent between ca. 1100 and 1750. Modern scholars, however, have generally not understood how the term was used in Roman law, medieval and early ...
Ken Pennington
doaj   +1 more source

Civil rights complaint process

open access: yes, 2009
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on June 11, 2009)Converted ...

core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Students with TBI

open access: yes, 2004
Title from PDF, p.
Ohio Legal Rights Service.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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