Results 181 to 190 of about 8,230,084 (364)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Neregularitati in modul instrumentalist de justificare a democratiei

open access: yesPerspective Politice, 2016
Urmatoarea lucrare isi propune sa prezinte o serie de caracteristici problematice ale argumentarii instrumentaliste propuse de Richard Arneson, precum si o critica adusa sistemului de delimitare a drepturilor în fundamentale si non-fundamentale. Lucrarea
Remus Daniel STANCIU
doaj  

Neutral Rights Upon the Seas [PDF]

open access: green, 1917
Frederic R. Coudert
openalex   +1 more source

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Born Too Soon: Progress and priorities for respectful and rights-based preterm birth care. [PDF]

open access: yesReprod Health
Kinney M   +11 more
europepmc   +1 more source

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