Results 111 to 120 of about 466,665 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Climate, nature, land-use change and human rights [PDF]

A transition to a low-carbon society is deeply needed, as a combined response to both the nature crisis and the climate crisis. To achieve a sustainable transition - built on inclusion, equity, and protection of nature and human rights - these challenges
Reed, Eilif Ursin, Tønnesen, Anders, Holmelin, Nina Bergan, Aamodt, Solveig, Vindegg, Mikkel, van Oort, Bob Erik, Bakkevoll, Sandra Elise, Standal, Karina   +7 more
core  

Civil litigation for environmental damages: are the so-called Rights of Nature an alternative?

This paper aims to analyse civil litigation for environmental damages and whether the so-called rights of nature are a viable alternative de lege ferenda. To this end, it examines (i) the participation of civil society in environmental protection through
Schumann Barragán, Guillermo José
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Rights and relationality: A review of the role of law in the human/water relationship

Water Alternatives
In this review, we use legal scholarship to explore the way that the law constructs and maintains discourses on both water rights and water relationality.
Erin O’Donnell, Cristy Clark, Rachel Killean   +2 more
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The Human Rights Act 1998: A Bill of Rights for Britain? [PDF]

, 2009
On the eve of the tenth anniversary of the coming into force of the Human Rights Act 1998 (HRA), this thesis endeavours to explore the extent to which New Labour’s flagship piece of legislation can be considered a Bill of Rights for Britain. It explores
TAYLOR, ROBERT,BRETT
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Programme : human rights and WTO teach-in

, 1999
Alternate title: Human rights teach-in on trading away human rights? The role of the WTO. Participants in teach-in include (in alphabetical order): Giampi Alhadeff (Solidar International), Walden Bello (Focus on the Global South), Beatrice Chaytor ...
People's Decade for Human Rights Education (PDHRE)
core