Results 41 to 50 of about 400,789 (264)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Hükümet Dışı Örgütlerin İnsan Hakları Hukukuna Etkileri: Doğa Hakları İçin Küresel İttifak ve Uluslararası Doğa Hakları Mahkemesi Örneği

open access: yesAnkara Hacı Bayram Veli Üniversitesi Hukuk Fakültesi Dergisi
Devletler ile toplum arasında köprü olma işlevi gören hükümet dışı örgütlerin önemi, iletişimin ve politikanın küreselleştiği, kolektif sorunların çoğaldığı günümüz kamusal yaşamında giderek artmaktadır.
Cansu Koc Basar
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

The role of cultural pluralism in Indigenous peoples’ defense of nature’s rights

open access: yesOñati Socio-Legal Series
Ecuador, by incorporating the Rights of Nature into its constitution, has presented an innovative approach to environmental protection, recognizing nature as a subject with rights.
Mohammadreza Jodyvash
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Nature of Human Rights

open access: yesRevista Latinoamericana de Derechos Humanos, 2016
In the formation of a new Constitution the constituents will require to know or reach an agreement on the nature of human rights; then, to determine how the State will enforce the respect to those rights.
Carlos López Dawson
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Rights of Nature and the Antarctic: An Introduction

open access: yesThe Polar Journal
This publication provides an introduction to The Polar Journal's Special Issue on Rights of Nature and the Antarctic. The Special Issue aims to advance the scholarly discussion on Antarctic RoN. The authors discuss the concept of RoN and its relevance for the Antarctic, the interconnections between RoN and the recognition of Antarctica’s intrinsic ...
Yousra Makanse   +2 more
openaire   +2 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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