Results 51 to 60 of about 371,968 (254)

The Nature of Solidarity Rights: Collective Rights or Peoples' Right [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2014
The efforts made by human rights scholars has  led to its classification according to the notion of “generational human rights”. Such generations include; the first generation (negative rights), the second generation (positive rights) and  the third or ...
Mohammad Ali Solhchi, Ramin Dargahi
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The role of cultural pluralism in Indigenous peoples’ defense of nature’s rights

Oñati Socio-Legal Series
Ecuador, by incorporating the Rights of Nature into its constitution, has presented an innovative approach to environmental protection, recognizing nature as a subject with rights.
Mohammadreza Jodyvash
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Rights of Nature and the Lake Erie Bill of Rights

Open Rivers
By Sheryl Cunningham. On February 26, 2019, citizens of Toledo, Ohio, passed legislation called the Lake Erie Bill of Rights (LEBOR), which created legal standing for nature in the state of Ohio by giving individual citizens the right to sue on behalf of
Sheryl Cunningham
doaj   +1 more source

Nature’s rights as Indigenous rights? Mis/recognition through personhood for Te Urewera

Espace populations sociétés, 2020
In Aotearoa New Zealand, person rights for nature have been added to the suite of resolution mechanisms for Treaty of Waitangi claims. New laws for two national parks personify landscapes and Maori relations with them to encourage greater appreciation ...
Brad Coombes
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Exploring contestation in rights of river approaches: Comparing Colombia, India and New Zealand

Water Alternatives, 2022
Rights of Nature (RoN) approaches as a tool to protect ecosystems and nature is gaining growing attention in academic and societal debates. Despite this new momentum, theoretical work is increasingly pointing out major problems and uncertainties ...
Marco Immovilli, Susanne Reitsma, Regine Roncucci, Elisabet Dueholm Rasch, Dik Roth   +4 more
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