Results 81 to 90 of about 3,322,138 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

The Rights of Nature: Three Models

open access: yesSortuz
This article considers whether an approach to the rights of nature (RoN) that reproduces rights and legal personality (which we will call the Extension Model) can achieve the goal of profoundly transforming our relationship with nature. The paper argues,
Joel Colon Rios, Marina Lostal
doaj   +1 more source

The politics of human nature [PDF]

open access: yes, 2016
Human nature is a concept that transgresses the boundary between science and society and between fact and value. It is as much a political concept as it is a scientific one.
Kronfeldner, Maria
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Trust and Distrust Approaches in the Constitutional Lawmaking of Rural Land Rights in Ethiopia: Nature, Drafting and Implications

open access: yesMizan Law Review, 2018
Although rural land rights are recognized in the 1995 Constitution of the Federal Democratic Republic of Ethiopia (FDRE), the academic discourse and policy dialogues on the issue are still underway.
Brightman Gebremichael
doaj   +1 more source

Are there customary rights to plants?: an inquiry among the Baganda (Uganda), with special attention to gender [PDF]

open access: yes
"Debates around Common Property Resources and Intellectual Property Rights fail to consider traditional and indigenous rights regimes that regulate plant resource exploitation, establish bundles of powers and obligations for heterogeneous groups of users,
Howard, Patricia L., Nabanoga, Gorettie
core  

Collaboration between unions in a multi-union, non-exclusive bargaining regime: What can Canada learn from New Zealand? [PDF]

open access: yes, 2012
The Canadian union certification system guarantees workers rights to organise, bargain collectively, and strike only when a majority of co-workers favours unionisation. This contravenes International Labour Organisation standards, in which the freedom to
Harcourt, Mark, Lam, Helen
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

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