Results 91 to 100 of about 46,857,055 (316)

Rigidity of Hawking mass for surfaces in three manifolds

open access: yes, 2017
It is well-know that Hawking mass is nonnegative for a stable constant mean curvature ($CMC$) sphere in three manifold of nonnegative scalar curvature. R. Bartnik proposed the rigidity problem of Hawking mass of stable $CMC$ spheres.
Sun, Jiacheng
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Investigation of the fluctuation of the static axial rigidity for double-nut preloaded ball screws

open access: yesAdvances in Mechanical Engineering, 2019
This article aims to investigate the fluctuation of the static rigidity for preloaded ball screws. Based on the correlation between preload and friction torque, a new model to calculate the contact rigidity by friction torque is proposed.
Kai Wang, Chang-guang Zhou, Yi Ou
doaj   +1 more source

Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect

open access: yesActa Pharmaceutica Sinica B, 2019
Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and ...
Hangyi Wu   +10 more
doaj   +1 more source

Linking Rigid Bodies Symmetrically

open access: yes, 2014
The mathematical theory of rigidity of body-bar and body-hinge frameworks provides a useful tool for analyzing the rigidity and flexibility of many articulated structures appearing in engineering, robotics and biochemistry.
Schulze, Bernd, Tanigawa, Shin-ichi
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

四种复合型柔性铰链刚度分析与应用

open access: yesJixie chuandong, 2013
According to the correlative knowledge of methods mechanics and calculus, the design equations for calculating the bending rigidity and stretching or compressing rigidity about the four kinds of composite flexural hinges are conducted. As an example, the
任宁, 耿铁, 周峰
doaj  

Orbit equivalence rigidity for ergodic actions of the mapping class group

open access: yes, 2008
We establish orbit equivalence rigidity for any ergodic, essentially free and measure-preserving action on a standard Borel space with a finite positive measure of the mapping class group for a compact orientable surface with higher complexity.
A. Connes   +14 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

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