Results 111 to 120 of about 862,711 (324)

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

A Linearly Deformable Pneumatic Scalable Microgripper for Universal Mid‐Air Micromanipulation

Advanced Science, EarlyView.
This work presents a fully 3D printed soft microgripper capable of active adhesion control through a pneumatic system. Its modular design can reach a high adhesion switching ratio of 373 and free release of micro‐objects at 100 μm$\umu \rm {m}$ dimension.
Jiawei Yi, Wissem Haouas, Gwenn Ulliac, Kanty Rabenorosoa   +3 more
wiley   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Parâmetros Doppler velocimétricos das artérias renais e da aorta abdominal em gatos da raça persa Doppler velocimetric parameters of aorta and renal arteries of Persian cats

Ciência Rural, 2009
Foi realizado um estudo prospectivo com 50 unidades renais de gatos adultos jovens da raça persa, as quais foram examinadas ao ultrassom Doppler. Os animais foram selecionados como sadios por meio de exames laboratoriais e de pressão arterial sistólica ...
Cibele Figueira Carvalho, Giovanni Guido Cerri, Maria Cristina Chammas   +2 more
doaj  

Synthesis and Characterization of trans-Dichlorotetrakis(imidazole)cobalt(III) Chloride: A New Cobalt(III) Coordination Complex with Potential Prodrug Properties

Bioinorganic Chemistry and Applications, 2018
Numerous therapies for the treatment of cancer have been explored with increasing evidence that the use of metal-containing compounds could prove advantageous as anticancer therapeutics.
Kaila F. Hart, Natalie S. Joe, Rebecca M. Miller, Hannah P. Nash, David J. Blake, Aimee M. Morris   +5 more
doaj   +1 more source

Por que a ingestão de carambola é proibida para pacientes com doença renal crônica?

Brazilian Journal of Nephrology, 2015
Resumo Novos estudos têm mostrado o mecanismo pelo qual a carambola (Averrhoa carambola) torna-se tóxica para indivíduos com doença renal crônica (DRC). O objetivo deste trabalho foi revisar a literatura atual sobre o tema. Trata-se de artigo de revisão,
Eduarda Savino Moreira de Oliveira, Aline Silva de Aguiar   +1 more
doaj   +1 more source

Micromachined Polycrystalline Sige-Based Thermopiles for Micropower Generation on Human Body [PDF]

, 2007
This paper presents a polycrystalline silicon germanium (poly-SiGe) thermopile specially designed for thermoelectric generators used on human body.
Fiorini, P., Leonov, V., Van Hoof, C., Wang, Z.   +3 more
core   +2 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Simultaneous Kidney Transplantation and Abdominoplasty in a Prune-Belly Syndrome Patient

Brazilian Journal of Transplantation, 2023
Simultaneous correction of the abdominal wall defect during kidney transplantation in a patient with Prune-Belly Syndrome (PBS) was not described yet. The abdominoplasty is postponed because the concomitant approach would result in greater complexity to
André Barcelos da Silva, Guilherme Alonso Daud Patavino, Miguel Bonfitto, Wilson Ferreira Aguiar, Renato Demarchi Foresto, Helio Tedesco-Silva, José Medina Pestana   +6 more
doaj