Results 61 to 70 of about 36,048 (301)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Selective Copolymerization from Mixed Monomers of Phthalic Anhydride, Propylene Oxide and Lactide Using Nano-Sized Zinc Glutarate

Nanomaterials
Selective polymerization with heterogeneous catalysts from mixed monomers remains a challenge in polymer synthesis. Herein, we describe that nano-sized zinc glutarate (ZnGA) can serve as a catalyst for the selective copolymerization of phthalic anhydride
Xiaoting Zhang, Zhidong Li, Liyan Wang, Jingjing Yu, Yefan Liu, Pengfei Song   +5 more
doaj   +1 more source

Synthesis of Poly(L-lactide) via Solvothermal Method

International Journal of Polymer Science, 2009
Poly(L-lactide) was obtained from the ring-opening polymerization of L-lactide through a solvothermal process. Tin (II) chloride (SnC12) was used as the catalyst for the polymerization reaction.
Ling Fang, Rongrong Qi, Linbo Liu, Gongwen Juan, Suangwu Huang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Ring-Opening Polymerization [PDF]

, 2013
Polymers can be synthesized by polymerizing monomers with ring structure as shown in Table 11.1. The polymerization of these compounds has some aspects of both chain and step polymerizations as far as kinetics and mechanisms are concerned. Table 11.1 Examples of polymers prepared by ring-opening polymerization [1] Polymer type ...
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Synthesis and properties of stereoregular fluoropolymers [PDF]

, 1986
The work described in this thesis was concerned with the synthesis and metathesis ring .opening polymerization of some fluorinated norbornenes and norbornadienes.
Blackmore, Patrique Michelle
core  

Investigation of Bioplastic Properties Developed from Acrylate Epoxidized Soybean Oil Through Ring Opening Polymerization Process [PDF]

, 2017
Soybean oil is one of the major vegetable oils containing more than 99% of triglycerides of saturated and unsaturated fatty acids and has become an interesting source to produce bioplastic.
Gupta, Arun, Hiew, Ming Yu, Gupta, Ritu, Husain, Muhamed Saad Bala   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Low melting point, high thermal stable branched benzoxazines resin derived from mixed-substituted phosphazene core

eXPRESS Polymer Letters, 2020
Six fluorine-containing, mix-substituted phosphazene-based branched benzoxazine monomers with a low melting point were successfully prepared and their chemical structures were verified by 1H, 13C, 31P and 19F nuclear magnetic resonance (NMR).
H-X. Ma, J-J. Qiu, C-M. Liu
doaj   +1 more source