Results 211 to 220 of about 3,697,738 (296)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Controlled formation of versatile methylated compounds based on ring opening of 4-methyl-1-siloxy-1,4-epoxy-1,4-dihydrobenzene. [PDF]

RSC Adv
Aijima T, Tokunaga J, Yoshimura S, Itabashi Y, Takehara T, Suzuki T, Akai S, Sawama Y.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Feasibility of the Belun sleep platform for obstructive sleep apnea diagnosis: A pilot case series from India. [PDF]

Lung India
Bhatia O, Tiwari P, Madan K, Mohan A, Hadda V, Suri TM, Mittal S.   +6 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

Cell
Chua NK, González-Robles TJ, Reddington CJ, Dudley-Fraser J, Birkinshaw RW, Han J, Solano A, Wong SW, Kochańczyk T, Peter JJ, Nakasone MA, Aust F, Munro J, Tong YH, Iskander J, Abeysekera W, Garnham A, Huckstep H, Ritchie ME, Wertz I, Hymowitz S, Kumar S, Conaway RC, Privé GG, Bullock AN, Babon JJ, Klevit RE, Lorenz S, Ciulli A, Fischer ES, Thomä NH, Nowak RP, Schulman BA, Rapé M, Rittinger K, Pagan JK, Bahlo M, Mackay JP, Mace PD, Lima CD, Hay RT, Komander D, Lechtenberg BC, Joazeiro CAP, Pagano M, Hofmann K, Feltham R.   +46 more
europepmc   +1 more source

Influence of Cycloalkane Carboxylic Acid Ring Size on Tribological Properties of TiN Coatings Under Lubricated Conditions. [PDF]

Materials (Basel)
Fu X, Fan Y, Jiang G, Zheng C, Wan Y.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source