Identification of the C9-hydrogenase for 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid (9,17-DOHNA) and the 7α-dehydratase essential for initiating β-oxidation of the B-, C-, and D-rings in steroid degradation by <i>Comamonas testosteroni</i> TA441. [PDF]
Appl Environ MicrobiolHorinouchi M.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Temporal Anti-Parity-Time Symmetry: Extending Non-Hermitian Physics to Time-Domain Dynamics in Thermal Diffusion. [PDF]
Research (Wash D C)Yan H, Li Y.
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Acquired Thrombotic Thrombocytopenic Purpura with a Poor Response to Treatment can be an Initial Manifestation of Occult Signet Ring Cell Carcinoma and other Malignancies. [PDF]
Eur J Case Rep Intern MedAhmad M +4 more
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Successful Emergency Removal of a Titanium Penile Constriction Ring Using Blood Aspiration and Nonpowered Bolt Cutters. [PDF]
CureusWeston GF, Golden BM.
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Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2. [PDF]
J Med ChemRomanyuk Z +16 more
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Multi-objective optimization design of oil spray cooling system for hairpin motor based on particle swarm optimization-backpropagation-non-dominated sorting genetic algorithm III. [PDF]
Sci RepLiu Y +5 more
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