Results 121 to 130 of about 284,604 (310)

Steroidal anticancer agents

open access: yes, 2001
This thesis describes the design, synthesis, and bioactivity of steroidal anticancer agents. The program aimed to discover new chemistry, provide concise routes to natural and analogue cytotoxins, and comprehend their structure-activity relationships ...
LaCour, Thomas Gerard
core  

Uranium, zirconium and hafnium eta8-permethylpentalene chemistry

open access: yes, 2013
The purpose of this project has been to expand the η8 binding mode of the permethylpentalene ligand into uranium, zirconium and hafnium chemistry. All three of these elements have shown intriguing, high-hapticity carbocyclic chemistry and, because of ...
O'Hare, Dermot M.   +1 more
core   +2 more sources

Basel Chemistry Symposium 2014 In Memory of Prof. T. Reichstein

open access: yesCHIMIA, 2015
Christophe Daeppen   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A new type of structure in sodium amide ring chemistry: crystal structure of [PhCH2(Me)NNa(tmeda)]2 showing a buckled, rather than the normal planar, (NNa)2 cyclic ring, with a cisoid, rather than the normal transoid, arrangement of amido-substituents (tmeda = tetramethylethylenediamine)

open access: yes, 1991
The red crystalline complex [PhCH2(Me)NNa(tmeda)]2, synthesised from equimolar proportions of PhNa, the secondary amine PhCH2(Me)NH and the Lewis base tmeda (tetramethylethylenediamine, Me2NCH2CH2NMe2), has been structurally identified by X-ray ...
MACGREGOR, M   +4 more
core   +1 more source

Basel Chemistry Christmas Symposium 2015

open access: yesCHIMIA, 2016
Andrea Pannwitz   +6 more
doaj   +1 more source

Chemistry of Small Ring Compounds. Part. I

open access: yesJournal of Synthetic Organic Chemistry, Japan, 1964
NISHIDA, Shinya, TSUJI, Takashi
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Some synthetic efforts in small ring chemistry

open access: yes
Cyclopropylcyclobutene was prepared via the intermediate dicyclopropylcarbinyl carbene which was generated by the thermal decomposition of the sodium salt of dicyclopropylketone p-toluenesulfonylhydrazone.
Lam, Luke Kwok Tung
core   +1 more source

Basel Chemistry Symposium 2013 In Memory of Prof. C. F. Schönbein

open access: yesCHIMIA, 2013
Patrick Burch   +5 more
doaj   +1 more source

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