Iminologous epoxide ring-closure. [PDF]
Chem Sci, 2022 Herein, we apply the principle of iminology to the well-established epoxide ring-closure reaction. The synthesis of tetrasubstituted, nitrile-tethered epoxides can be achieved via activation of iminologous diols followed by fragmentation. Mechanistic study reveals the transformation to be stereoretentive, which is consistent with the concerted nature ...
Tien CH, Lough AJ, Yudin AK.
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Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was evaluated
Mohammed Farrag El-Behairy +8 more
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MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis [PDF]
Nature CommunicationsThe eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull +11 more
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Embryonic ring closure: Actomyosin rings do the two-step. [PDF]
J Cell Biol, 2016 Actomyosin rings drive numerous closure processes, but the mechanisms by which they contract are still poorly understood. In this issue, Xue and Sokac (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201608025) show that actomyosin ring closure during Drosophila melanogaster cellularization uses two steps, only one of which involves Myosin-2.
Martin AC.
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Case report of secondary angle closure glaucoma from a Soemmering's ring presenting with episodes of transient total monocular vision loss [PDF]
American Journal of Ophthalmology Case ReportsPurpose: To describe an interesting case of a Soemmering's ring causing intermittent secondary angle closure glaucoma presenting as painless transient monocular vision loss (TMVL).
Sarah Zhou +3 more
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Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins [PDF]
Journal of the Serbian Chemical Society, 2021 5-Alkenyl hydantoins and alkenyl spirohydantoins are converted into bicyclic and tricyclic hydantoins, under indirect electrochemical conditions, generating the phenylselenyl cation in situ. The reactions proceeded in good to exelent yields.
Šmit Biljana M. +4 more
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Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis
Nature Communications, 2023 Cytokinesis plays crucial roles in morphogenesis. Previous studies have examined how tissue mechanics influences the position and closure direction of the contractile ring.
Christina Rou Hsu +4 more
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7-Bromo-[1,2,5]selenadiazolo[3,4-d]pyridazin-4(5H)-one
Molbank, 2021 New heterocyclic systems containing 1,2,5-chalcogenadiazoles are of great interest for the creation of organic photovoltaic materials and biologically active compounds. In this communication, 3,6-dibromopyridazine-4,5-diamine was investigated in reaction
Timofey N. Chmovzh, Oleg A. Rakitin
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3-(4-(Benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine
Molbank, 2023 The [1,2,4]triazolo[4,3-a]pyridine derivative 3-(4-(benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine was prepared in a 73% isolated yield by means of an oxidative ring closure of a hydrazine intermediate.
Katrina E. Doherty +3 more
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Closure formula for ideals in intermediate rings
Applied General Topology, 2020 In this paper, we prove that the closure formula for ideals in C(X) under m topology holds in intermediate ring also, i.e. for any ideal I in an intermediate ring with m topology, its closure is the intersection of all the maximal ideals containing I.
John Paul Jala Kharbhih, Sanghita Dutta
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