Results 41 to 50 of about 77,990 (262)
Binding Constants of Substituted Benzoic Acids with Bovine Serum Albumin
Pharmaceuticals, 2020 Experimental data on the affinity of various substances to albumin are essential for the development of empirical models to predict plasma binding of drug candidates. Binding of 24 substituted benzoic acid anions to bovine serum albumin was studied using
Diliara Khaibrakhmanova +2 more
doaj +1 more source
Dynamical black rings with a positive cosmological constant [PDF]
Physical Review D, 2009 11 pages, 16 figures, references ...
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sensors, 2019 This study proposes a high-sensitivity microwave sensor based on an interdigital-capacitor-shaped defected ground structure (IDCS-DGS) in a microstrip transmission line for the dielectric characterization of planar materials.
Junho Yeo, Jong-Ig Lee
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The operator rings of topological symmetric orbifolds and their large N limit
Journal of High Energy PhysicsWe compute the structure constants of topological symmetric orbifold theories up to third order in the large N expansion. The leading order structure constants are dominated by topological metric contractions.
Sujay K. Ashok, Jan Troost
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Generators of rings of constants for some diagonal derivations in polynomial rings
Journal of Pure and Applied Algebra, 1995 Let \(K\) be a field of characteristic zero. The authors show that if \(n\geq 3\), that given \(r\geq 0\) there exists a diagonal \(K\)-derivation of \(K[x_1, \dots, x_n]\) such that the minimal number of generators over \(K\) of the ring of constants is equal to \(r\).
Nowicki, Andrzej, Strelcyn, Jean-Marie
openaire +2 more sources