Results 181 to 190 of about 118,983 (259)

Dynamic changes in volatile flavor compounds and capsaicinoids and their interrelationships in eight chili pepper cultivars across three ripening stages. [PDF]

Food Chem X
Jia Q, Bi W, Yang T, Zhang R, Han J, Sha H, Wang Y, Han D, Zhu Z, Su D.   +9 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Effect of Rennet Type on Selenium Retention and Its In-Vitro Bioaccessibility in Se-Enriched Edam Cheese: An Exploratory Study. [PDF]

Foods
Praus L, Legarová V, Kejdová Rysová L, Šrámek M, Kaplan L, Sedlář O, Tlustoš P, Száková J.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hierarchical Regulatory Module AcERF1-AcHAT5-AcERF10 Modulates Ethylene-Dependent Starch Degradation in Postharvest Kiwifruit. [PDF]

Plant Biotechnol J
Zhang Y, Chen J, Hu H, Yang C, Xie K, Yang C, Kai W, Chen C, Yang Y, Zeng J, Chen M, Gan Z.   +11 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Regulatory structural variations upstream of a NAC transcription factor control fruit maturity timing in peach. [PDF]

J Exp Bot
Tagliabue AG, Friel J, Chiozzotto R, Baccichet I, da Silva Linge C, Calastri E, Biffi G, Zaracho N, Gattolin S, Micali S, Eduardo I, Bassi D, Rossini L, Cirilli M.   +13 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Changes in Quality Characteristics, Microbial Communities, and Metabolomic Profiles of Mianning Ham During Different Aging Periods. [PDF]

Foods
Deng Y, Wang Z, Han J, Zhou L, Wang X, Zhang J, Liu B, Chen W.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source