Results 131 to 140 of about 14,252 (249)
circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer
Cancer Science, EarlyView.circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang +4 more
wiley +1 more source
Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer
Cancer Science, EarlyView.Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang +7 more
wiley +1 more source
Cancer Science, EarlyView.tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley +1 more source
Child &Family Social Work, EarlyView.ABSTRACT This study aimed to examine the predictive power of problem‐solving skills and maternal parenting attitudes on the resilience levels of 5‐year‐old children living in socio‐economically disadvantaged communities. The study sample consisted of 208 five‐year‐old children attending independent kindergartens affiliated with the Ministry of National
Sümeyye Safali Turan +1 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim To investigate the association between baseline plasma α‐hydroxybutyrate (α‐HB), an organic acid derived from aminoacid catabolism and glutathione anabolism, and the 10‐year incidence of Type 2 diabetes (T2DM). Materials and Methods This prospective study analysed 1349 participants from the Swedish PAROKRANK study.
Elena Fortin +5 more
wiley +1 more source
Confidential Computing on RISC-V
Getting confidential computing right is a tough challenge. Other architectures already tried in the past to introduce mechanisms for providing confidentiality guarantees, and in many cases failed. On RISC-V the Confidential Computing SIG, under the Security HC, is working on two specifications for providing confidentiality guarantees for VMs/TEEs and ...
openaire +2 more sources
Stress and Resilience Development in German Dental Students
European Journal of Dental Education, EarlyView.ABSTRACT Introduction The study evaluated the effectiveness of a resilience training for dental students as a preventive measure for mental health and stress management, with consideration for its long‐term integration into dental education. Methods A 2‐day online resilience training was tailored to address specific stressors experienced by dental ...
Leonie X. Lin +3 more
wiley +1 more source
RNA activation in insects: From emerging evidence to molecular applications
Insect Molecular Biology, EarlyView.Canonical RNA activation involves small RNAs interacting with promoter sequences, but there is also evidence of non‐canonical RNAa in eukaryotes. Emerging evidence suggests the presence of RNAa in insects. RNAa can be utilised as a tool for functional genomic studies in insects.
Sassan Asgari
wiley +1 more source
Evaluating the WE CARE Program's Impact on Job Satisfaction and Intent to Leave
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim This project team aims to (1) evaluate the effectiveness of the Workforce Engagement for Compassionate Advocacy, Resilience, and Empowerment (WE CARE) program in improving the work environment, workplace mental health, and nurse outcomes, and (2) examine underlying factors influencing job satisfaction and intent to leave among staff nurses.
Aoyjai P. Montgomery +6 more
wiley +1 more source