Results 181 to 190 of about 81,703 (295)

Recent Advances in Reversed‐Phase Liquid Chromatography for Therapeutic Oligonucleotide and Conjugate Characterization: From Ion‐Pairing to Green Analytical Approaches

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Therapeutic oligonucleotides (ONs) have rapidly emerged as a novel class of treatments in the pharmaceutical industry, with over 25 medicines approved in the past decade. Ion‐pair reversed‐phase liquid chromatography coupled with mass spectrometry (IP‐RPLC‐MS) is widely used method for ON characterization.
Quang‐Dong Bui, Weronika Hewelt‐Belka, Tiny Deschrijver, Martin Gilar, Sebastiaan Eeltink   +4 more
wiley   +1 more source

Psychological Resilience and Quality of Life in Mycosis Fungoides Patients: A BIO-MUSE Study. [PDF]

Acta Derm Venereol
Johansson A, Velickovic K, Belfrage E, Drott K, Johnsson P, Ek S.   +5 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Tissue specific RISC-loading reassesses small RNA functionality in developing pepper fruit. [PDF]

Plant Mol Biol
Dalmadi Á, Gyula P, Abdu A, Kis A, Miloro F, Bálint J, Szittya G, Havelda Z.   +7 more
europepmc   +1 more source

Circular RNA circERBB2 Promotes Tumorigenesis via the miR‐1587/CBX2 Axis and Epigenetic Silencing of PTEN in Bladder Cancer Cells

MedComm – Oncology, Volume 5, Issue 4, December 2026.
circERBB2, originating from backsplicing of ERBB2 pre‑mRNA, is robustly upregulated in bladder cancer (BLCA) and acts as a miR‑1587 sponge to derepress chromobox 2 (CBX2). CBX2 subsequently recruits EZH2 to catalyze H3K27me3 deposition at the PTEN promoter, epigenetically silencing this tumor suppressor and unleashing the PI3K/AKT/mTOR cascade to drive
Xiang Pan, Xi Chen, Kailai Chen, Feng Pei, Li Zhong, Yunqi Li, Wenchao Shi, Jian Ma, Yakun Luo   +8 more
wiley   +1 more source

Individualized physiological readiness over an admission-time denominator - a reply to comments on rapid sequence versus early surgical stabilization of severe chest wall injuries. [PDF]

Crit Care
Spering C, Lefering R, Lehmann W, Schulz-Drost S.   +3 more
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Achieving 1.0-s Thermally Activated Delayed Fluorescence via Synergistic Control of Reverse Intersystem Crossing and Exciton Cycling. [PDF]

Angew Chem Int Ed Engl
Lei Y, Liu R, He Y, Luo G, Liu C, Su J, Li B, Long X, Tan Y, Luo Y, Qiu H, Huang Y, Lu Z.   +12 more
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, Volume 13, Issue 61, 3 November 2026.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source