Results 51 to 60 of about 35,633 (259)

Nitro Reduction‐Based RNA Control and Ultrafast Release

Angewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao, Senfeng Zhang, Junsong Guo, Tuan‐Khoa Kha, Song Chen, Chunyi Hu, Ru‐Yi Zhu   +6 more
wiley   +2 more sources

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

A Blue Emissive Heavy Atom‐Free Multiresonant Thermally Activated Delayed Fluorescent Emitter Shows Ultra‐Fast Reverse Intersystem Crossing

Angewandte Chemie, EarlyView.
The extended π‐system and low‐lying n‐π∗ transition endow DDOBDiKTa with a synergistic combination of strong spin‐orbit coupling, small reorganization energy and small ΔEST, enabling this blue boron‐nitrogen‐carbonyl hybrid emitter to achieve a fast kRISC of 6.34 × 106 s−1 together with OLEDs showing small efficiency roll‐off, with EQEmax/EQE10000 of ...
Wenrui Wang, Hassan Hafeez, Sen Wu, Aidan P. McKay, David B. Cordes, Ifor D. W. Samuel, Eli Zysman‐Colman   +6 more
wiley   +2 more sources

RISC++: Towards an HLS Defined RISC-V SoC

2025 28th Euromicro Conference on Digital System Design (DSD)
The relevance of heterogeneous architectures has significantly increased over the last decade due to stagnation of performance scaling. Concurrently, increased performance-energy tradeoff requirements driven by the growth of edge computing, with a large focus on Artificial Intelligence (AI) inference, further motivates efforts towards hardware ...
Guilherme Vareiro De Oliveira, Vinicius Pirassoli, Luís Miguel Sousa, Nuno Paulino 0001   +3 more
openaire   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

La autoevaluación para la mejora de la seguridad integral en centros educativos

Educar, 2014
La seguridad no es una condición que se dé de manera espontánea en los centros educativos. Su presencia requiere articular mecanismos que permitan conocer y hacer un seguimiento de los riesgos presentes, tanto en el interior como en el exterior del ...
Joaquín Gairín, Anna Díaz Vicario, Manuel Rosales Acín, Xavier Sentinella Soler   +3 more
doaj   +1 more source

Integrated Optoelectronic Model to Predict the External Quantum Efficiency of Single‐Layer TADF Organic Light‐Emitting Diodes

Advanced Electronic Materials, EarlyView.
An experimentally validated optoelectronic device model is presented to describe the efficiency and roll‐off behavior of single‐layer TADF OLEDs. By coupling charge transport, exciton dynamics, and optical outcoupling, the model reproduces the External Quantum Efficiency (EQE) across different emission layer thicknesses and temperatures, offering ...
Jawid Nikan, Kaiwen Guo, Yungui Li, Paul W. M. Blom, Gert‐Jan A. H. Wetzelaer   +4 more
wiley   +1 more source

Heterologous expression and characterization of polyhydroxyalkanoate synthase genes from haloarchaeal strains in Haloferax mediterranei

Frontiers in Microbiology
IntroductionPolyhydroxyalkanoates (PHAs) are promising materials for building a sustainable society due to their excellent biodegradability. Some haloarchaea, which require high salt concentrations for growth, possess class III PHA synthases (PhaECs) and
Keisuke Wada, Kazunori Ushimaru, Shun Sato, Tokuma Fukuoka   +3 more
doaj   +1 more source

Estimarea igienică a stării de sănătate a lucrătorilor expuși riscului acțiunii pesticidelor

One Health & Risk Management, 2023
Introducere. Sănătatea constituie valoarea cea mai de preţ și o componentă de bază a dezvoltării și prosperării sociale. O preocupare a sănătății publice este domeniul de gestionare a pesticidelor – surse de pericol pentru sănătatea angajaților.
Mariana ZAVTONI, Vladimir BERNIC, Elena BUCATA   +2 more
doaj  

Dual Impact of Long‐Lived Localized Carriers Induced by Restricted Hole Transfer in Organic Photovoltaics and Photocatalytic Hydrogen Evolution

Advanced Energy Materials, EarlyView.
This work clarifies why organic semiconductors perform differently in photovoltaic devices and photocatalytic nanoparticles. By examining D18:Y5 and PM6:Y6 systems, we show how aggregation, exciton lifetime, and interfacial charge transfer behavior govern energy‐conversion pathways.
Gayoung Ham, Sanghyeok An, Wooteak Jung, Hyun Min Kwon, Seonghyeon Kang, Jaehyuk Lee, Sowon Kim, Changwoo Park, Damin Lee, Young Yong Kim, Sungjin Jo, Chang Yun Son, Sae Byeok Jo, Dae Sung Chung, Hyojung Cha   +14 more
wiley   +1 more source