Results 61 to 70 of about 81,703 (295)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

RISC micrprocessor verification

CoRR, 2020
Today's microprocessors have grown significantly in complexity and functionality. Most of today's processors provide at least three levels of memory hierarchy, are heavily pipelined, and support some sort of cache coherency protocol. These features are extremely complex and sophisticated, and present their own set of unique verification challenges ...
Mitul S. Nagar, Haresh A. Suthar, Chintan Panchal   +2 more
openaire   +2 more sources

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

RISC++: Towards an HLS Defined RISC-V SoC

2025 28th Euromicro Conference on Digital System Design (DSD)
The relevance of heterogeneous architectures has significantly increased over the last decade due to stagnation of performance scaling. Concurrently, increased performance-energy tradeoff requirements driven by the growth of edge computing, with a large focus on Artificial Intelligence (AI) inference, further motivates efforts towards hardware ...
Guilherme Vareiro De Oliveira, Vinicius Pirassoli, Luís Miguel Sousa, Nuno Paulino 0001   +3 more
openaire   +2 more sources

Hardware Acceleration of Stochastic Neural Networks Enabled by Bit‐Cell Level Co‐Design of Magnetic Tunnel Junctions

Advanced Science, EarlyView.
An MTJ‐based probabilistic processing‐in‐memory architecture unites nonvolatile storage, local entropy generation, and stochastic computation within each memory cell. Stored multi‐bit weights are converted directly into programmable stochastic bitstreams, enabling neural‐network inference, adaptive Ising optimization, and uncertainty‐aware Bayesian ...
Qiuyuan Wang, Dooyong Koh, Brooke McGoldrick, Tudor Mocioi, Yabin Fan, Marc Baldo, Luqiao Liu   +6 more
wiley   +1 more source

RISC Validity Project

, 2023
This study extends the Relational-Interdependent Self-Construal (RISC) measure to the study of romantic relationships. See "RISC STUDY MANUAL" under the project's documents for all content related to the study's development and ...
Caleb A. Myatt, Manfred van Dulmen, Karly A. Cochran   +2 more
core   +2 more sources

Beyond Radical Emitters: Hot‐Exciton Electroluminescence From Singlet Diradicaloids

Angewandte Chemie, EarlyView.
The first hot‐exciton mechanism in a singlet diradicaloid is demonstrated in a polychlorinated Thiele hydrocarbon‐based organic light‐emitting transistor. Reverse intersystem crossing involving the T2 and bright singly excited states enables electroluminescence beyond the 25% spin‐statistical limit, leading to remarkable external quantum efficiency ...
Mario Prosa, Eugenio Lunedei, Michele Orza, Davide Mesto, Roberto Cantoni, Francesco Reginato, Angela Punzi, Arthur R. J. Barreto, Yasi Dai, Benedetta Carlotti, Fabrizia Negri, Stefano Toffanin, Davide Blasi   +12 more
wiley   +2 more sources

La autoevaluación para la mejora de la seguridad integral en centros educativos

Educar, 2014
La seguridad no es una condición que se dé de manera espontánea en los centros educativos. Su presencia requiere articular mecanismos que permitan conocer y hacer un seguimiento de los riesgos presentes, tanto en el interior como en el exterior del ...
Joaquín Gairín, Anna Díaz Vicario, Manuel Rosales Acín, Xavier Sentinella Soler   +3 more
doaj   +1 more source

De-RISC – Dependable Real-Time Infrastructure for Safety-Critical Computer Systems [PDF]

, 2020
Publicat en accés amb el permís de l'editor / Published in open access with the permission of the publisher.The space domain demands increased performance, reliable and easy to verify and validate platforms tomatch the requirements of highly autonomous
Nicolau, Vicente, Gómez, Francisco, Trilla, David, Gallego, Felipe, Cabo, Guillem, Andersson, Jan, Masmano, Miguel, Abella Ferrer, Jaume, Le Rhun, Jimmy   +8 more
core   +1 more source