Results 91 to 100 of about 6,520,117 (303)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The role of chief risk officer in adoption and implementation of enterprise risk management-A literature review [PDF]
, 2012 Recently many companies view risk management from a holistic approach instead of a silo- based perspective. This holistic approach is called Enterprise Risk Management (ERM).
Abdul Rasid, Siti Zaleha +3 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A generalized risk approach to path inference based on hidden Markov models
, 2012 Motivated by the unceasing interest in hidden Markov models (HMMs), this paper re-examines hidden path inference in these models, using primarily a risk-based framework. While the most common maximum a posteriori (MAP), or Viterbi, path estimator and the
Koloydenko, Alexey A., Lember, Jüri
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Development of a flowchart of the processes of a risk-based MRO system applied to mining enterprises
Горное оборудование и электромеханикаThis article discusses the key aspects of developing process flowcharts for risk-based maintenance and repair (MRO) systems. The main attention is paid to the study of the methodology for creating such schemes that take into account various types of ...
Chernyh V.G. +5 more
doaj +1 more source
Bank insolvency risk and aggregate Z-score measures: a caveat [PDF]
We demonstrate that a popular approach to constructing (weighted) mean-based aggregate bank insolvency risk measures is inherently biased; we also suggest an alternative approach that avoids this problem.insolvency risk, aggregate Z-score, Jensen's ...
Frank Strobel
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Risk Management Model from the Perspective of the Implementing ISO 9001:2015 Standard Within Financial Services Companies [PDF]
Amfiteatru Economic, 2017 In its new form, the ISO 9001:2015 standard activates and utilizes a thought pattern based on risk assessment functioning in parallel with the implementation of the system regarding quality management.
Cătălina Sitnikov +3 more
doaj