Emergent data influences the risk/benefit assessment of hemophilia gene therapy using recombinant adeno-associated virus. [PDF]
Front Med (Lausanne), 2023 Puetz J.
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
States of Uncertainty, Risk-Benefit Assessment and Early Clinical Research: A Conceptual Investigation. [PDF]
Sci Eng Ethics, 2022 Schnarr A, Mertz M.
europepmc +1 more source
Prevalence of nutrition risk and associated social risk factors in community living older adults in the New Zealand Health, Work and Retirement Study : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Nutrition and Dietetics at Massey University, Auckland, New Zealand [PDF]
, 2017 Background: The New Zealand population is ageing as a result of declining mortality and birth rates. In order for older adults to remain in optimal health, good nutrition is vital.
Tkatch, Melaney Tema
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Risk-benefit assessment of shifting from traditional meat-based diets to alternative dietary patterns. [PDF]
EFSA J, 2022 Mihalache OA, Dellafiora L, Dall'Asta C.
europepmc +1 more source
Risk-Benefit Assessment of Intense Blood Pressure Lowering [PDF]
Hypertension, 2019 Jordan, J., Tank, J., Reuter, H.
openaire +2 more sources
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
Belimumab or anifrolumab for systemic lupus erythematosus? A risk-benefit assessment. [PDF]
Front Immunol, 2022 Kirou KA +3 more
europepmc +1 more source