Results 11 to 20 of about 7,404 (210)

A prospective multicentric study of risk-reducing salpingo-oophorectomy in BRCA mutation patients. [PDF]

Acta Biomed, 2022
Background and aim of the work: BRCA1/2 are tumour-suppressor genes involved in DNA homologous recombination and ovarian cancer development.  The study evaluated the risk of tumor cancer in women presenting the BRCA mutations. Methods: Risk-reducing surgery (RRS) was performed in 100 patients carrying BRCA1 (aged between 30-73 years, median age was 51 ...
Loizzi V, Cicinelli E, Del Vecchio V, Arezzo F, Deromemaj X, Kardhashi A, Paradiso A, Legge F, Natalicchio MI, Resta L, Resta N, Loconte DC, Cormio G.   +12 more
europepmc   +2 more sources

Uptake of Risk‐Reducing Salpingo‐Oophorectomy and Gynaecologic Surveillance Among Germline BRCA Pathogenic Variants Carriers [PDF]

Cancer Medicine
Introduction Risk‐reducing salpingo‐oophorectomy (RRSO) is recommended by international guidelines in women with BRCA1/2 germline pathogenic variants (PV) to prevent ovarian cancer.
Alessandra Inzoli, Serena Negri, Cristina Dell'Oro, Clarissa Costa, Liliana Marchetta, Mariaclara Boccadutri, Simona Fumagalli, Gaia Roversi, Elena Maria Sala, Chiara Celi, Valentina Rossi, Robert Fruscio   +11 more
doaj   +2 more sources

An explainable machine learning ensemble model to predict the risk of ovarian cancer in BRCA-mutated patients undergoing risk-reducing salpingo-oophorectomy [PDF]

Frontiers in Oncology, 2023
IntroductionIt has been estimated that 19,880 new cases of ovarian cancer had been diagnosed in 2022. Most epithelial ovarian cancer are sporadic, while in 15%–25% of cases, there is evidence of a familial or inherited component. Approximately 20%–25% of
Maria Colomba Comes, Francesca Arezzo, Francesca Arezzo, Gennaro Cormio, Gennaro Cormio, Samantha Bove, Angela Calabrese, Annarita Fanizzi, Anila Kardhashi, Daniele La Forgia, Francesco Legge, Isabella Romagno, Vera Loizzi, Vera Loizzi, Raffaella Massafra   +14 more
doaj   +2 more sources

Risk of Peritoneal Carcinomatosis After Risk-Reducing Salpingo-Oophorectomy: A Systematic Review and Individual Patient Data Meta-Analysis. [PDF]

J Clin Oncol, 2022
PURPOSE After risk-reducing salpingo-oophorectomy (RRSO), BRCA1/ 2 pathogenic variant (PV) carriers have a residual risk to develop peritoneal carcinomatosis (PC). The etiology of PC is not yet clarified, but may be related to serous tubal intraepithelial carcinoma (STIC), the postulated origin for high-grade ...
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA.   +21 more
europepmc   +5 more sources

Determinants of intention to undergo risk-reducing salpingo-oophorectomy among high-risk women for breast and ovarian cancer [PDF]

Scientific Reports
To evaluate the intention of women at high risk for breast and ovarian cancer to undergo risk-reducing salpingo-oophorectomy (RRSO) after genetic testing, and to identify the main factors related to their decision-making.
Bárbara Narciso Duarte, Daniel Imbassahy de Sá Bittencourt Câmara e Silva, Thiago Gaspar, Christine Elisabete Rubio Alem, Ana Elisa Ribeiro da Silva Cabello, Sandra Regina Campos Teixeira, Ana Lídia Viaro, Cesar Cabello   +7 more
doaj   +2 more sources

Impact of risk-reducing salpingo-oophorectomy in premenopausal women

Climacteric, 2017
To describe implications of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on quality of life, endocrine symptoms, sexual function, osteoporosis, cardiovascular health, metabolic syndrome, cognitive impairment and safety of hormone replacement therapy.We searched the following electronic databases: The Cochrane Library, EMBASE, PsycInfo, and ...
Vermeulen, R F M, Beurden, M van, Korse, C M, Kenter, G G   +3 more
exaly   +7 more sources

Role of Routine Peritoneal Biopsies During Risk Reducing Salpingo-Oophorectomy (RRSO). [PDF]

Geburtshilfe Frauenheilkd, 2021
Abstract Objective The objective of this retrospective study was to assess the role of routine peritoneal biopsies during risk reducing salpingo-oophorectomy (RRSO). Methods Data of 204 women who underwent RRSO between January 1, 2014 and February 20, 2020 at Charité – Universitätsmedizin Berlin, Campus Mitte were retrospectively ...
Pross T, Karsten MM, Blohmer JU, Speiser D.   +3 more
europepmc   +3 more sources

Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women. [PDF]

Gynecologic Oncology, 2015
OBJECTIVE: To define risk thresholds for cost-effectiveness of risk-reducing salpingo-oophorectomy (RRSO) for ovarian cancer (OC) prevention in low/intermediate risk postmenopausal women.
Legood, R, Manchanda, R, Menon, U, Pearce, L   +3 more
core   +4 more sources

Risk-reducing strategies for women carrying brca1/2 mutations with a focus on prophylactic surgery [PDF]

BMC Women's Health, 2010
Background Women who have inherited mutations in the BRCA1 or BRCA2 genes have substantially elevated risks of breast and ovarian cancer. Mutation carriers have various options, including extensive and regular surveillance, chemoprevention and risk ...
Mokbel Kefah, Bismohun Selina, Salhab Mohamed   +2 more
doaj   +3 more sources

Validation of machine learning-based models to predict and explain the risk of ovarian cancer: a multicentric study on BRCA-mutated patients undergoing risk-reducing salpingo-oophorectomy [PDF]

Frontiers in Oncology
ObjectiveBRCA-mutated women are recommended to undergo bilateral risk-reducing salpingo-oophorectomy (RRSO) after childbearing, due to the lack of effective methods that could be able to early detect the occurrence of ovarian cancer.
Vera Loizzi, Vera Loizzi, Maria Colomba Comes, Francesca Arezzo, Adriana Ionelia Apostol, Adriana Ionelia Apostol, Samantha Bove, Annarita Fanizzi, Robert Fruscio, Robert Fruscio, Vanesa Gregorc, Francesco Legge, Rosanna Mancari, Claudia Marchetti, Claudia Marchetti, Serena Negri, Serena Negri, Giorgia Russo, Laura Vertechy, Giovanni Scambia, Giovanni Scambia, Raffaella Massafra, Gennaro Cormio, Gennaro Cormio   +23 more
doaj   +2 more sources