Results 61 to 70 of about 1,462,025 (323)

What risk of death would people take to be cured of HIV and why? A survey of people living with HIV

Journal of Virus Eradication, 2019
People living with HIV (PLWHIV) can reasonably expect near-normal longevity, yet many express a willingness to assume significant risks to be cured. We surveyed 200 PLWHIV who were stable on antiretroviral therapy (ART) to quantify associations between ...
Benjamin R. Murray, Allison Kratka, Karen A. Scherr, Nir Eyal, Jennifer Blumenthal-Barby, Kenneth A. Freedberg, Daniel R. Kuritzkes, James K. Hammitt, Regina Edifor, Madelaine N. Katz, Kathryn I. Pollak, Brian J. Zikmund-Fisher, Scott D. Halpern, Mary C. Barks, Peter A. Ubel   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Factors affecting adolescents' risk-taking in single-child families

Social Health and Behavior, 2019
Introduction: Given the current concerns about population decline and the prevalence of single-child families, as well as risky behaviors which are increasing in the community, there is a need to provide backgrounds for more information regarding the ...
Tahereh Ataei, Reza Zeighami, Nezal Azh, Maryam Mafi   +3 more
doaj   +1 more source

Offenders’ risk-taking attitude inside and outside the prison walls [PDF]

, 2014
It has long been assumed that risk taking is closely associated with criminal behavior. One reason for placing criminals behind bars—aside from punishment and protecting the public—is to prevent them from engaging in further risky criminal activities ...
Aiken, Anderson, Becker, Binswanger, Binswanger, Bird, Blais, Boys, Brown, Cohen, Darke, De Groot, Fazal, Fromme, Fromme, Frost, Gardner, Gottfredson, Hanoch, Hanoch, Kennedy, Kleef, Levitt, Markiewicz, McEvoy, Merrall, Nixon, Rolison, Siegrist, Simon, Spaulding, Tanaka, Turner, Visschers, Weber, Weild, Weller, Williams   +37 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Les enseignants débutants face à l’inanticipable : les « meilleurs moments d’enseignement » comme points de bascule

Questions Vives
We study “best teaching moments” from the point of view of the unanticipated. We analyze posts published on a digital collaborative logbook by pre-service language teachers in lycée or collège.
Marie-Claire Lemarchand-Chauvin, Sophie Necker, Joséphine Rémon   +2 more
doaj   +1 more source

Linking relational capabilities and entrepreneurial orientation of an organization

International Entrepreneurship Review, 2020
Objective: The aim of the paper is to examine relational capabilities of an organization in the context of entrepreneurial orientation and to identify potential interconnection between them. Research Design & Methods: The sample consists of 363 small-
Rafał Kusa
doaj   +1 more source

Tournament Rewards and Risk Taking [PDF]

I consider two seemingly unrelated puzzles; 1.Why is relative performance evaluation (RPE) used less in CEO compensation than agency theory suggests? 2.Why is sometimes, e.g., for fund managers, a mediocre performance more highly rewarded than excellence?
Hans K. Hvide
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source