Results 251 to 260 of about 25,767,497 (405)

Breast cancer risk level and prediction of tumor aggressiveness in the Athena Breast Health Network. [PDF]

Breast Cancer Res Treat
Leggat-Barr K, Lewis T, Tice JA, Tsopurashvili E, Sayaman R, Warner P, Malvin K, Sabacan L, Perry-Solomon A, Theiner S, Acerbi I, Griffin A, McGuire J, Lee V, Borowsky AD, Wisdom Study and Athena Breast Health Network Investigators and Advocate Partners, Eklund M, Kaplan C, Hiatt RA, Fiscalini AS, Kerlikowske K, Shieh Y, Esserman L, Van't Veer L.   +23 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study

Circulation, 2008
R. D'Agostino, R. Vasan, M. Pencina, P. Wolf, M. Cobain, J. Massaro, W. Kannel   +6 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A prediction rule to identify low-risk patients with community-acquired pneumonia.

New England Journal of Medicine, 1997
M. Fine, T. Auble, D. Yealy, B. Hanusa, L. Weissfeld, Daniel E. Singer, C. Coley, T. Marrie, W. Kapoor   +8 more
semanticscholar   +1 more source

Moving toward equitable juvenile justice risk assessments for adolescents: Considering clinical, community, and statistical fairness. [PDF]

Psychol Assess
Cohen JR, Stutts MS, Govender T, Fishbach JS, Shorey RC, Hardesty JL.   +5 more
europepmc   +1 more source

Risk Factors for Cytomegalovirus Viremia following Liver Transplantation With a Seropositive Donor and Seronegative Recipient Receiving Antiviral Therapy

, 2020
Nina Singh, Drew J. Winston, Raymund R. Razonable, G. Marshall Lyon, Fernanda P. Silveira, Marilyn M. Wagener, Ajit P. Limaye   +6 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Individual Risk Attitudes: Measurement, Determinants and Behavioral Consequences

, 2009
Thomas Dohmen, A. Falk, David Huffman, U. Sunde, Jürgen Schupp, G. Wagner   +5 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source