Results 101 to 110 of about 10,758,089 (294)

RoB 2: a revised tool for assessing risk of bias in randomised trials

British medical journal, 2019
Assessment of risk of bias is regarded as an essential component of a systematic review on the effects of an intervention. The most commonly used tool for randomised trials is the Cochrane risk-of-bias tool. We updated the tool to respond to developments
J. Sterne, J. Savović, M. Page, R. Elbers, N. Blencowe, I. Boutron, C. Cates, Hung-Yuan Cheng, M. Corbett, S. Eldridge, J. Emberson, M. Hernán, S. Hopewell, A. Hrõbjartsson, D. Junqueira, P. Jüni, J. Kirkham, T. Lasserson, Tianjing Li, A. McAleenan, B. Reeves, S. Shepperd, I. Shrier, L. Stewart, K. Tilling, I. White, P. Whiting, J. Higgins   +27 more
semanticscholar   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Autoimmunity and risk assessment.

Environmental Health Perspectives, 1999
Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development in order to improve risk ...
Petia P. Simeonova, Randy Gallucci, Joanna M. Matheson, Michael I. Luster   +3 more
openaire   +2 more sources

Developing a framework of minimum standards for the risk assessment of alien species

, 2018
1. Biological invasions are a threat to biodiversity, society and the economy. There is an urgent need to provide evidence-based assessments of the risks posed by inva-sive alien species (IAS) to prioritize action.
H. Roy, W. Rabitsch, R. Scalera, A. Stewart, B. Gallardo, P. Genovesi, F. Essl, T. Adriaens, S. Bacher, O. Booy, E. Branquart, S. Brunel, G. Copp, Hannah J. Dean, B. D'hondt, M. Josefsson, M. Kenis, M. Kettunen, Merike Linnamagi, F. Lucy, A. Martinou, Niall Moore, W. Nentwig, A. Nieto, J. Pergl, J. Peyton, A. Roques, Stefan Schindler, K. Schönrogge, W. Solarz, P. Stebbing, T. Trichkova, S. Vanderhoeven, J. V. Valkenburg, A. Zenetos   +34 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

ASSESSMENT OF RISK OF HUMAN INFECTION IN THE MICROBIOLOGICAL LABORATORY [PDF]

, 1969
Arnold G. Wedum, Richard H. Kruse
openalex   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Journal of the American Medical Association (JAMA), 2018
Importance Incorporating nontraditional risk factors may improve the performance of traditional multivariable risk assessment for cardiovascular disease (CVD).
Jennifer S. Lin, Corinne V. Evans, Eric S. Johnson, N. Redmond, Erin L. Coppola, N. Smith   +5 more
semanticscholar   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Serotype distribution and antimicrobial resistance characteristics of Salmonella in chicken meat collected from wholesale markets in Beijing City

Zhongguo shipin weisheng zazhi
ObjectiveTo investigate the serotype distribution and antimicrobial resistance characteristics of Salmonella isolated from retail chicken in Beijing City.MethodsA total of 135 Salmonella strains were isolated from retail chicken meat collected from three
HU Yujie, WEN Yi, MA Yanning, HE Yingying, JIANG Tao, YU Dongmin, BAI Yao, XU Jin, LI Fengqin, DONG Yinping   +9 more
doaj   +1 more source