Results 111 to 120 of about 6,297,835 (358)

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

open access: yesFEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui   +3 more
wiley   +1 more source

Developing an Actuarial Risk Assessment to Inform the Decisions Made by Adult Protective Service Workers [PDF]

open access: yes, 2010
In 2008, the New Hampshire Department of Health and Human Services Bureau of Elderly and Adult Services (BEAS) and the National Council on Crime and Delinquency (NCCD), with funding provided by the National Institute of Justice (NIJ), collaborated to ...
Andrea Bogie   +3 more
core  

Autoimmunity and risk assessment.

open access: yesEnvironmental Health Perspectives, 1999
Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development in order to improve risk ...
M I, Luster   +3 more
openaire   +2 more sources

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

open access: yesFEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro   +8 more
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Yellow fever resurgence: An avoidable crisis?

open access: yesnpj Vaccines, 2022
Nicole P. Lindsey   +10 more
doaj   +1 more source

[Risk assessment].

open access: yesLa Medicina del lavoro, 2011
Erano le dodici di sabato 4 dicembre 2010. Dopo quattro giornate di congresso, i medici del lavoro avevano finalmente raggiunto l'orario fissato per ottenere i crediti formativi, e con la scheda delle risposte ai quiz diligentemente compilata si erano messi in fila davanti all'addetto al rilascio. Centinaia di medici, forse più di un migliaio, avevano
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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