Results 131 to 140 of about 6,017,024 (357)
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Public Comment on OMB Draft Risk Assessment Bulletin [PDF]
The OIRA draft Risk Assessment Bulletin has worthy intentions and has stimulated useful review and discussion.; Most previous major documents in the development of the risk assessment field have been cited and used appropriately.
Omenn, Gilbert S.
core +1 more source
Fire risk assessment – from property to people [PDF]
, 2014 Two studies sponsored by the Nottinghamshire Fire and Rescue Service, one into the assessment and management of risk, and the other on effective communication, picked up the top two prizes in this year’s Fire Related Research and Developments ...
Greenhalgh, K, Murphy, P
core
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Proceedings of the Symposium on the Assessment of Exposure and Risk [PDF]
, 1974 W. R. Lee
openalex +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Environment InternationalObjective: Headache is one of the most prevalent and disabling health conditions globally. We prospectively explored the urban exposome in relation to weekly occurrence of headache episodes using data from the Dutch population-based Occupational and ...
Eugenio Traini +5 more
doaj +1 more source
Response : Models for Carcinogenic Risk Assessment [PDF]
, 1978 Jerome Cornfield
openalex +1 more source
Farm Level Risk Assessment Using Downside Risk Measures [PDF]
Recent and presumable future developments tend to increase the risk associated with farming activities. This causes an increasing importance of risk management.
Berg, Ernst, Starp, Michael
core +1 more source