Results 91 to 100 of about 825,360 (268)

Biosafety and Biosecurity: A relative risk-based framework for safer, more secure and sustainable laboratory capacity building

Frontiers in Public Health, 2015
Background: Laboratory capacity building is characterized by a paradox between endemicity and resources: Countries with high endemicity of pathogenic agents often have low and intermittent resources (water, electricity) and capacities (laboratories ...
Petra eDickmann, Heather eSheeley, Nigel Francis Lightfoot, Nigel Francis Lightfoot   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Risk Communication with Patients

YAKUGAKU ZASSHI, 2012
Recently, the Ministry of Health, Labour and Welfare has made efforts toward the strengthening of dissemination of appropriate drug and safety information through information service for healthcare professionals. Furthermore, Pharmaceuticals and Medical Devices Agency (PMDA) enforced webpages regarding drug safety information tools, such as PMDA ...
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Narrative strategies in wild-mushroom-poisoning prevention videos: focus-group study among Chinese university students

BMJ Open
Background Wild mushroom poisoning represents a significant global public health challenge, with China experiencing particularly high incidence rates.
Yu Chen, Jing Xu, Si Chen, Xinjie Zhao, Yanxi Ding   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Using health belief model constructs to understand the role of perceived disease threat and resilience in responding to COVID-19 among people who use drugs: a cluster analysis

Advances in Drug and Alcohol Research
IntroductionThe Health Belief Model (HBM) has been successfully applied to understanding adherence to COVID-19 prevention practices. It has not, however, been used to understand behavior in people who use drugs (PWUD).
Kirsten Paulus, Kirsten Paulus, Sarah Bauerle Bass, Sarah Bauerle Bass, Patrick J. A. Kelly, Jenine Pilla, Jenine Pilla, AnnaMarie Otor, AnnaMarie Otor, Madison Scialanca, Madison Scialanca, Anamarys Arroyo, Anamarys Arroyo, Namaijah Faison, Namaijah Faison   +14 more
doaj   +1 more source

Media and Uncertainty| Media and Uncertainty—Introduction

International Journal of Communication, 2022
  The institutions of media and journalism are troubled by uncertainty. Attacked by populist politicians and disrupted by the platform economy, the media are expected to defend democracy by disseminating reliable and meaningful information while helping ...
Nelson Ribeiro, Barbie Zelizer
doaj  

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source