Results 91 to 100 of about 7,503,171 (257)

Models evaluating reliability of monoand multiproduct chains at industrial enterprise

open access: yesУченые записки Российской академии предпринимательства, 2021
In this article, the problem of risk reliability estimation functioning in production-technological systems of mono- and multiproduct enterprises is reviewed.
M. A. Khalikov, M. A. Nikiforova
doaj  

Incorporating prediction and estimation risk in point-in-time credit portfolio models [PDF]

open access: yes
In this paper we focus on the analysis of the effect of prediction and estimation risk on the loss distribution, risk measures and economic capital. When variables for the determination of probability of default and loss distribution have to be predicted
Wildenauer, Nicole   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

20210727_RAG_PRA_Health risk after flooding

open access: yes, 2021
RAG PRA Health risk after  ...
Risk Assessment Group
core  

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

The risk of acquiring the new influenza A(H1N1) for Brazilian travelers to Chile, Argentina and the USA

open access: yesMemorias do Instituto Oswaldo Cruz, 2010
We estimate the risk of acquiring the new influenza A(H1N1) for Brazilian travelers to Chile, Argentina and the USA. This is done by a mathematical model that quantifies the intensity of transmission of the new virus in those countries and the ...
Eduardo Massad   +3 more
doaj   +1 more source

Robustness analysis and convergence of empirical finite-time ruin probabilities and estimation risk solvency margin. [PDF]

open access: yes
We consider the classical risk model and carry out a sensitivity and robustness analysis of finite-time ruin probabilities. We provide algorithms to compute the related influence functions.
Stéphane Loisel   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Robust estimation of operational risk

open access: yes, 2022
S.3-30According to the loss distribution approach, the operational risk of a bank is determined as the 99.9% quantile of the respective loss distribution, covering unexpected severe events. The 99.9% quantile can be considered a tail event.
Bae, T., Horbenko, N., Ruckdeschel, P.
core   +1 more source

Home - About - Disclaimer - Privacy