Results 71 to 80 of about 5,094,715 (305)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Scientific Reports
Tau proteins as neurofibrillary tangles are one of the molecular hallmarks of Alzheimer’s disease (AD) and play a central role in tauopathies, a group of age-related neurodegenerative disorders.
Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocca   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Risk Factors of Recipient Receiving Living Donor Liver Transplantation in the Comprehensive Era of Indication and Perioperative Managements [PDF]

, 2010
2010-08Living donor liver transplantation (LDLT) has become one of the chief methods of saving patients with end-stage liver disease due to liver cirrhosis.
Nakamura, Taro, Goto, Hidemi, Ishigami, Masatoshi, Ito, Akihiro, Hayashi, Kazuhiko, Onishi, Yasuharu, Katano, Yoshiaki, Hirooka, Yoshiki, Kiuchi, Tetsuya   +8 more
core   +1 more source

Total α and β radioactivity levels of source water in two areas of Shanghai from 2012 to 2022

Shanghai yufang yixue
ObjectiveThe purpose was to understand the background level of environmental radioactivity in the surrounding area of Qinshan Nuclear Power Plant and accumulate historical monitoring data of radioactivity in the environment， in order to detect and deal ...
HUANG Minpeng, QIAN Aijun, LUO Fajian, GAO Linfeng   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Facile Fabrication of Flower-Like BiOI/BiOCOOH p–n Heterojunctions for Highly Efficient Visible-Light-Driven Photocatalytic Removal of Harmful Antibiotics

Nanomaterials, 2019
Novel heterojunction photocatalysts with remarkable photocatalytic capabilities and durability for degrading recalcitrant contaminants are extremely desired; however, their development still remains quite challenging.
Shijie Li, Bing Xue, Chunchun Wang, Wei Jiang, Shiwei Hu, Yanping Liu, Hengwei Wang, Jianshe Liu   +7 more
doaj   +1 more source

Risk Factors for Dementia

Journal of the Formosan Medical Association, 2009
Dementia is a complex human disease. The incidence of dementia among the elderly population is rising rapidly worldwide. In the United States, Alzheimer's disease (AD) is the leading type of dementia and was the fifth and eighth leading cause of death in women and men aged > or = 65 years, respectively, in 2003.
Jen-Hau Chen, Kun-Pei Lin, Yen-Ching Chen   +2 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source