Results 61 to 70 of about 3,892,802 (298)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Research on the pollution characteristics of typical hazardous wastes in the non-ferrous smelting industry

能源环境保护
The National Catalogue of Hazardous Wasteis the primary legal document for identifying hazardous wastes and also provides the foundation for its environmental management in China. The non-ferrous smelting industry involves a complex process with numerous
WANG Fei, LI Xuebing, HUANG Qifei* , YANG Yufei   +3 more
doaj   +1 more source

High-level collapse risk identification based on oblique photography and InSAR technology

Shuiwen dizhi gongcheng dizhi, 2023
Collapse risk identification is the basis of collapse disaster prevention. High level collapse is characterized by sudden, hidden and large height difference, which brings great challenges to information collection, disaster identification and risk ...
Pengwei WANG, Yuke AN
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Exposure to responsible components of PM2.5 induces hepatic steatosis: An in silico, in vitro, and in vivo study based on adverse outcome pathway

Ecotoxicology and Environmental Safety
Mounting evidence suggests that exposure to PM2.5 is closely associated with hepatic steatosis. However, due to the complex composition of PM2.5, evidence regarding the effects of its specific chemical components on hepatic steatosis remains insufficient.
Zhipeng Yan, Nan Nan, Yue Wang, Bi Luo, Yaru Zhang, Shiya Li, Dou Dang, Guohua Qin   +7 more
doaj   +1 more source

Presenting a Method for Evaluating the Safety Risk Management Process in Industries Using Fuzzy Logic Approach [PDF]

Archives of Occupational Health, 2021
Background: An effective process for preventing industrial accidents basically requires a thorough study of the environment, data collection, evaluation, and analysis of this information, determination of corrective action, and its implementation.
Hamidreza Mehri, Faeze Sepahi-Zoeram, Ali Karimi, Farideh Golbabaei   +3 more
doaj  

Risk Assessment for Developmental Toxicity: Airborne Occupational Exposure to Ethanol and Iodine [PDF]

, 1991
Dean Mattison explains hazard identification, hazard characterization and exposure characterization as furnishing a foundation for Risk assessment generally. He then illustrates their application in assessing the fetal Risk posed by two common substances.
Mattison, Donald R.
core   +1 more source

Predicting deadline transgressions using event logs [PDF]

, 2013
Effective risk management is crucial for any organisation. One of its key steps is risk identification, but few tools exist to support this process. Here we present a method for the automatic discovery of a particular type of process-related risk, the ...
A.K. Jallow, J.A. Wickboldt, M. Jans, P. Zhang, P.J. Rousseeuw, W.M.P. Aalst van der   +5 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Ozone exposure at environmental level induces female reproductive impairment via transcriptomic and alternative analysis

Ecotoxicology and Environmental Safety
Ozone (O3) exposure caused oxidative damage, which released inflammatory biomarkers into the circulation, triggered systemic effects that disrupted female hormonal levels and impacted the reproductive system, but its underlying mechanisms remained ...
Xiaomin Liang, Xiaoyun Wu, Yuchai Tian, Huizhen Zhu, Jiyue Zhang, Yangcheng Hu, Bin Li, Xiaotong Ji, Huifeng Yue   +8 more
doaj   +1 more source