Results 91 to 100 of about 6,723,402 (312)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Features of the immune status and comorbidities in children with alopecia areata

Медицинская иммунология
Increased incidence of alopecia has been noted in children at the present time. Participation of autoimmune (immunopathological) mechanisms in pathogenesis of this disease necessitates additional study of immune status and characteristics of comorbid ...
I. E. Shtina, L. V. Osheva, O. V. Ermakova, A. I. Matyanina   +3 more
doaj   +1 more source

IT-Risk Management

, 2000
E-Business Risk ist eine Kombination von Gesch?ftsmodell und Technologie. Gegenstand eines effektiven und effizienten IT-Risk Managements ist folglich die Verbindung von Gesch?ftsmodell und Technologie. Es wird als Gesamtheit aller Ma?nahmen, Prozesse und Institutionen verstanden, die auf eine zielgerichtete Gestaltung der vom Informationsmanagement ...
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Real-world insights of patient voices with age-related macular degeneration in the Republic of Korea and Taiwan: an AI-based Digital Listening study by Semantic-Natural Language Processing

BMC Medical Informatics and Decision Making
Background In this era of active online communication, patients increasingly share their healthcare experiences, concerns, and needs across digital platforms.
Hyewon Jeon, Su-Yeon Yu, Olga Chertkova, Hyejung Yun, Yi Lin Ng, Yan Yoong Lim, Irina Efimenko, Djoubeir Mohamed Makhlouf   +7 more
doaj   +1 more source

Integrated forest fires management in Morocco

Biodiversidade Brasileira, 2019
A new national strategy for prevention and fight against forest fires is being developed in Morocco. The establishment of this strategy is carried out step by step. The first step helped to better understand the Moroccan territorial context and concrete
Fouad Assali, Hubert D'Avezac De Castera, Hicham Mharzi Alaoui, Samir Taberkant, Anass nabaha   +4 more
doaj   +1 more source

Risk management: understanding why is as important as understanding how [PDF]

, 2010
The management of risk is a key area within a number of ACCA papers, and exam questions related to this area are common. It is vital that students are able to apply risk management techniques, such as using derivative instruments to hedge against risk ...
Malde, S
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Key to Risk Management: Management [PDF]

The Barings, Daiwa Bank and Sumitomo Corp. financial debacles in the mid-1990s suggest that management failures rather than misfortune, errors, or complexity are a major source of the risk of financial debacles.
Adrian E. Tschoegl
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source