Results 111 to 120 of about 2,968,291 (287)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Якутский медицинский журналWe studied changes in the level of biochemical and general clinical indicators (thyroid-stimulating hormone, apolipoproteins, cortisol, serotonin, adrenaline, leukocytes, erythrocyte sedimentation rate) in children living under the adverse factors of the
N. V. Zaitseva +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Multidimensional food security in North Eastern Amhara: a CARI based agroecological analysis
Discover SustainabilityThe North Eastern Amhara Region is prone to drought, making the pursuit of food security a significant challenge. In this context, a multidimensional food security analysis can provide policymakers with the insights needed for timely interventions.
Henock Abate Demessia +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Opportunity windows accelerate action and expand options for climate adaptation in Europe
Communications Earth & EnvironmentClimate adaptation must be intensified globally to keep up with increasing climate change impacts. To date, adaptation is mostly driven by climate risks that need to be reduced and little by opportunities. We identify opportunity windows -i.e. favourable
Valeria Di Fant +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Remote SensingAccurate and rapid delineation of wildfire-affected areas is essential in the era of climate-driven increases in fire frequency. This study compares and analyzes four techniques for identifying wildfire-affected areas using Sentinel-2 satellite imagery: (
Sang-Hoon Lee +5 more
doaj +1 more source