Results 111 to 120 of about 4,696,317 (312)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Enhancing carbon sinks in China using a spatially-optimized forestation strategy

Nature Communications
China plans expanding 49.5 million hectares of new forests by 2050 to strengthen carbon sequestration. However, estimates of the carbon benefits from this expansion rarely consider the effect of ‘forest edge’, where tree mortality increases under ...
Yanli Dong, Zhen Yu, Thomas Pugh, Evgenios Agathokleous, Fangmin Zhang, Stephen Sitch, Weibin You, Wangya Han, Stefan Olin, Shirong Liu, Guoyi Zhou, Pedro Cabral, Pengsen Sun   +12 more
doaj   +1 more source

Concurrent Decadal Trend Transitions of Sea Ice Concentration and Sea Surface pCO₂ in the Beaufort Sea

Remote Sensing
Interannual climate changes and increasing atmospheric CO2 (AtmCO2) have significantly altered sea surface partial pressure of CO2 (pCO2) in the Beaufort Sea (BS).
Shangbin Chi, Meibing Jin
doaj   +1 more source

Risk management and nonbank participation in the U.S. retail payments system [PDF]

The retail payments system in the United States has changed significantly in recent years. Advances in technology have caused a greater reliance on electronic payment networks. And the industrial structure of the payment services industry has evolved, as
Richard J. Sullivan
core  

[Further Development of Maturity Levels of Quality and Risk Management System at the University Hospital Schleswig-Holstein]. [PDF]

Gesundheitswesen, 2023
Soeth E, Hilbert C, Scharffenberg S, Wehkamp K, Rogge A, Kahla-Witzsch H, Freitag-Wolf S, Scholz J, Petzina R.   +8 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Long-term satellite records of water clarity suggest increasing human activity influence in an inland lake

International Journal of Digital Earth
Water clarity is a key indicator of trophic status and lake health, yet its long-term trends and driving factors remain underexplored due to limited historical data.
Jian Wang, Deyong Sun, Shengqiang Wang, Hailong Zhang, Yue Zhang, Miao He   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Capital adequacy and risk management - premises for strengthening financial system stability [PDF]

In the last decades, we have witnessed the progressive integration of European financial system, as a result of the cumulative effect of markets' liberalization, innovation and globalisation, and of harmonization of the regulations and implementation of ...
Bunea-Bontaş, Cristina Aurora, Lăzărică, Marinela, Petre, Mihaela Cosmina   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source