Results 91 to 100 of about 4,696,317 (312)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparative Analysis of dNBR, dNDVI, SVM Kernels, and ISODATA for Wildfire-Burned Area Mapping Using Sentinel-2 Imagery

Remote Sensing
Accurate and rapid delineation of wildfire-affected areas is essential in the era of climate-driven increases in fire frequency. This study compares and analyzes four techniques for identifying wildfire-affected areas using Sentinel-2 satellite imagery: (
Sang-Hoon Lee, Myeong-Hwan Lee, Tae-Hoon Kang, Hyung-Rai Cho, Hong-Sik Yun, Seung-Jun Lee   +5 more
doaj   +1 more source

Spatial and Temporal On-Farm Risk Management - Crop Production Scheduling and Index Insurance Strategies [PDF]

An agronomic crop growth model, Decision Support System for Agro-Technology Transfer (DSSAT), is used to find optimal crop management strategies for cotton production in Mitchell, Miller, and Lee Counties in Georgia during the past 10 years.
Hoogenboom, Gerrit, Lin, Shanshan, Mullen, Jeffrey D.   +2 more
core   +1 more source

Towards Automating the Construction & Maintenance of Attack Trees: a Feasibility Study

, 2014
Security risk management can be applied on well-defined or existing systems; in this case, the objective is to identify existing vulnerabilities, assess the risks and provide for the adequate countermeasures.
Paul, Stéphane
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Intrinsic Timing Relationship Between Tropical Cyclone Maximum Intensification Rate and Lifetime Maximum Intensity

Geophysical Research Letters
The intensification rate (IR) equation, derived from a time‐dependent simplified energetically based dynamical system (EBDS), links tropical cyclone (TC) intensity, IR, and their evolutions, suggesting a connection between the timing of TC lifetime ...
Qingyang Xiong, Qiaoyan Wu
doaj   +1 more source

Risk-Management for Data Warehouse Systems [PDF]

, 2001
Data warehouse projects are notoriously difficult to manage and many of them end in failure. One explanation for the high failure rate is that managers are not taking prudent measures to assess and manage the risks involved in the data warehouse project. In this paper we introduce the goal-driven risk management approach of the easyREMOTEDWH framework.
Robert M. Bruckner, Beate List, Josef Schiefer   +2 more
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Design and Validation of an Edge-AI Fire Safety System with SmartThings Integration for Accelerated Detection and Targeted Suppression

Applied Sciences
This study presents the design and validation of an integrated fire safety system that leverages edge AI, hybrid sensing, and precision suppression to overcome the latency and collateral limitations of conventional smoke detection and sprinkler systems ...
Seung-Jun Lee, Hong-Sik Yun, Yang-Bae Sim, Sang-Hoon Lee   +3 more
doaj   +1 more source

Prospective, multicenter validation of the deep learning-based cardiac arrest risk management system for predicting in-hospital cardiac arrest or unplanned intensive care unit transfer in patients admitted to general wards. [PDF]

Crit Care, 2023
Cho KJ, Kim JS, Lee DH, Lee SM, Song MJ, Lim SY, Cho YJ, Jo YH, Shin Y, Lee YJ.   +9 more
europepmc   +1 more source