Results 191 to 200 of about 5,312,301 (290)

Cancer Treatment-Related Cardiotoxicity among Survivors of Childhood Cancer: A Comparative and Integrated View of Multiple Measures of Biological Age Acceleration. [PDF]

Cancer Epidemiol Biomarkers Prev
Meng X, Eulalio T, Oh K, Plonski NM, Shelton K, Mulder HL, Easton J, Zhang J, Walker EV, Neale G, Srivastava DK, Howell RM, Mandelblatt JS, Ky B, Dixon SB, Armstrong GT, Hudson MM, Ness KK, Wang Z.   +18 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Plasma Metabolite Associations for Risk and Laboratory Measures of Type 2 Diabetes in a Large-Scale Finnish Prospective Cohort. [PDF]

Diabetes Care
Liu L, Peng R, Chu X, Xia Z, Fu Q, Fernandes Silva L, Stringham HM, Hu X, Liang Y, Ji X, Li J, Yang T, Morrison J, Wen X, Fauman E, Burant CF, Scott LJ, Boehnke M, Laakso M, Yin X.   +19 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

The Utility of Measures of Physical Behavior, Function, and Fitness as Predictors of Mortality. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Wang Y, Razieh C, Rowlands AV, Bakrania K, Russell R, Khunti K, Davies MJ, Zaccardi F, Yates T.   +8 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The relative contribution of modifiable and non-modifiable factors for determining cognition in mid-life individuals at risk for late-life Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Cao B, Qi Q, Hutchinson S, Ferguson D, Malhotra P, Koychev I, O'Brien JT, Bridgeman K, Ritchie CW, Lawlor B, Naci L, PREVENT Dementia Investigators.   +11 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Theoretical Considerations for Patient-Specific Modeling Based on Observable State Variables. [PDF]

J Biomech Eng
Ateshian GA, Deiters S, Weiss JA.
europepmc   +1 more source