Results 181 to 190 of about 2,942,669 (315)

A Dynamic Model of Extreme Risk Coverage: Resilience and Efficiency in the Global Reinsurance Market

, 2011
Sabine Lemoyne de Forges, Ruben Bibas, Stéphane Hallegatte   +2 more
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma. [PDF]

Front Genet
Zhao Q, Xie H, Li C, Xiong Y, Fan Y, Huang Y, Zhan Y, Zeng S.   +7 more
europepmc   +1 more source

Production Support Model to Manage Market Demand Volatility Risks

, 2016
Anders Johansson, Lars Pejryd, Linn Gustavsson Christiernin   +2 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Nationwide Multicenter Study of Advanced Endoscopic Resection and Malignant Risk Model for Gastric Myogenic Tumors (GASTRO Trial). [PDF]

Life (Basel)
Fan CT, Shieh TY, Hsu WH, Chien HY, Lee CT, Chen MY, Lee CY, Tai WC, Shiu SI, Cheng IC, Chung CS.   +10 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Preoperative risk model and nomogram for 30‑Day mortality after TAVR: development and internal validation in a Chinese cohort. [PDF]

BMC Surg
Li H, Liu C, Chen P, Wang S, Li X, Luo X, Xie Y, Wang X, Wang L.   +8 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Development of the MSKP index: Risk model of musculoskeletal pain in Colombian adolescents. [PDF]

PLoS One
Alfonso-Mora ML, Sánchez-Vera MA, Uribe-Laverde MA, García Becerra AM, Gonzalez PS.   +4 more
europepmc   +1 more source